Survival and Treatment Outcomes of Resectable Cholangiocarcinoma: Initial Experience in Khon Kaen Hospital

Authors

  • Pornchai Theerachotpakorn Department of Surgery, Khon Kaen Hospital
  • Surachai Siripornadulsilp Department of Surgery, Khon Kaen Hospital
  • Titi Weerapriyakul Department of Surgery, Khon Kaen Hospital
  • Nititep Laithawatthana Department of Surgery, Khon Kaen Hospital
  • Prakasit Siritus Department of Surgery, Khon Kaen Hospital
  • Thanyawan Hieangratch Department of Surgery, Khon Kaen Hospital

Keywords:

Cholangiocarcinoma surgery

Abstract

Background: The most effective current treatment for cholangiocarcinoma is surgical resection. Khon Kaen Hospital receives a significant number of cholangiocarcinoma patients, and it is essential to analyze the treatment outcomes and survival to improve future treatment processes.

Methods: A retrospective study that analyzes the treatment outcomes and survival of cholangiocarcinoma patients who underwent surgery at Khon Kaen Hospital between October 2014 to September 2019. The study covers patient demographics, disease characteristics, surgical information, treatment outcomes, complications, and survival analysis.

Results: There were a total of 84 predominantly male patients with an average age of 63 years. Most patients had intrahepatic type and presented with abdominal pain and jaundice. The most common complication was wound infection, 14%, and the overall perioperative mortality rate was 8%. The perihilar type had the highest mortality rate. The median survival time was 16.8 months, with the intrahepatic type having the most prolonged survival (23.2 months), followed by distal type (16.5 months) and perihilar type (9.2 months). These differences were statistically significant (P-value < 0.01). Positive margins and lymph node involvement were significant factors associated with shorter survival times.

Conclusion: Surgical treatment of cholangiocarcinoma at Khon Kaen Hospital is generally safe, with complication and mortality rates comparable to other research studies. Key factors for long-term survival include achieving a negative microscopic margin (R0 resection) and the absence of lymph node involvement.

References

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TJS 44-4 02

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Published

2023-12-28

How to Cite

1.
Theerachotpakorn P, Siripornadulsilp S, Weerapriyakul T, Laithawatthana N, Siritus P, Hieangratch T. Survival and Treatment Outcomes of Resectable Cholangiocarcinoma: Initial Experience in Khon Kaen Hospital. Thai J Surg [Internet]. 2023 Dec. 28 [cited 2024 Nov. 25];44(4):141-9. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/265498

Issue

Vol. 44 No. 4 (2023): October - December

Section

Original Articles

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