Rapid Antibiotics Guideline for Treatment and Management of COVID-19 Pneumonia with Bacterial Co-infection
Keywords:
COVID-19 infection, Pneumonia, AntibioticsAbstract
Background: There are many patients having serious or critical illness will require hospital admission due to SARS-CoV-2 pneumonia. While antibiotics are ineffective for treatment of viral infections, they are prescribed in patients with suspected or documented SARS-CoV-2 for a variety of reasons. This raises concerns of antibiotic overuse or receiving unnecessary antibiotics and increase antimicrobial resistance (AMR).
Objective: The authors would like to develop a rapid antibiotic guideline for the treatment of patients with SARS-CoV-2 who have coinfections. These recommendations are intended to ensure the better antibiotic management of suspected or confirmed bacterial pneumonia in adults during the SARS-CoV-2 pandemic.
Methods: We used MEDLINE, OVID Epub and EMBASE searches complemented with extensive use of Web engine to identify guidelines on empirical treatment of community and hospital-acquired pneumonia in the last 10 years.
Results: We could develop antibiotic prescribing recommendation for patients with suspected community-acquired pneumonia, that has developed before or within 48 hours and patients with suspected hospital acquired pneumonia at more than 48 hours of admission.
Conclusion: Patients who develop SARS-CoV-2 pneumonia can have guideline for antibiotic prescription in case of suspected secondary superimp
References
Hu B, Guo H, Zhou P, Shi Z-L. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol 2021; 19 (3): 141-54.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 2020; 382 (8): 727-33.
D’Amico F, Baumgart DC, Danese S, Peyrin-Biroulet L. Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management. Clin Gastroenterol Hepatol 2020; 18 (8):1663-72.
Han C, Duan C, Zhang S, Spiegel B, Shi H, Wang W, et al. Digestive Symptoms in COVID-19 Patients with Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes. Am J Gastroenterol 2020; 115 (6): 916-23.
Tabata S, Imai K, Kawano S, Ikeda M, Kodama T, Miyoshi K, et al. Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis. Lancet Infect Dis 2020; 20 (9):1043-50.
Chedid M, Waked R, Haddad E, Chetata N, Saliba G, Choucair J. Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy. J Infect Public Health 2021; 14 (5): 570-6.
Guan W-j, Ni Z-y, Hu Y, Liang W-h, Ou C-q, He J-x, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020; 382 (18):1708-20.
Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, et al. Clinical Characteristics of Covid-19 in New York City. N Engl J Med 2020; 382 (24):2372-4.
Perlman S, Dandekar AA. Immunopathogenesis of coronavirus infections: implications for SARS. Nat Rev Immunol 2005; 5 (12): 917-27.
Ginsburg AS, Klugman KP. COVID-19 pneumonia and the appropriate use of antibiotics. Lancet Glob Health 2020; 8 (12): e1453-e4.
Armitage R, Nellums LB. Antibiotic prescribing in general practice during COVID-19. Lancet Infect Dis 2020; (20): 30917-8.