Rice Starch Anchor for Osteoporotic Bone Strengthening

Abstract

Background: Osteoporosis and osteopenia are important diseases for weakening and fracturing the bones of patients. Both diseases are caused by low bone mass and deterioration of bone structure until severe pain and unable to function normally. Most doctors will treat bone fractures using a metal plate and screw to hold the bone in place. Then fix and pull the bone back to its original position by using screws to fix the bone. But in osteoporosis, the screw is usually to be wobble without tighten bone fixation.

Objective: This research aims to increase bone mass in specific position that enhances bulk structure by implanting the rice starch bone anchor into the porous bone.

Materials and methods: Rice starch anchor (RSa) was carried out in third steps. Characteristics of the final products were then investigated scanning electron microscopy (SEM), XRD, and swelling ratio, PH and, pull out strength. All quantitative data were analyzed with origin 8.0 (Origin Lab Corporation, USA) and presented as the mean ± standard deviation. Statistical comparisons were carried out using analysis of variance (ANOVA, Origin 8.0). A value of p < 0.05 was considered to be statistically significant. Materials characteristics were determined by scanning electron microscopy (SEM), X-ray diffraction (XRD) and swelling ratio.

Result: The material was completely biodegradable in the human body. The optimal composition of the material is 50% of rice starch, 50 wt % of additives. It had physical characteristics. In parts that can be used to hold human bones, such as the upper tibia below the knee joint. The rice anchor can be used 3.95 mm of metal screws with a pullout strength of 117.27 ± 1.58 N.

Conclusion: Rice starch anchor had chemical and mechanical properties suitable for used with metal screws to help hold screws tighten in decayed surfaces for human bone fixation. It was suitable material for bone strengthening of osteoporosis. In the future should be tested for compatibility in laboratory animals and further testing for safety and clinical efficacy.