The effectiveness of intraosseous injection for supplemental anesthesia in impacted lower third molar surgery

Main Article Content

Kanjana Singkharotai
Rapeeporn Malungpaishrope
Vanutsanun Theprod
Kanitha Pajonklaew
Khemjira Ummaralikit
Rawisara Pantien
Chitaroon Sukvitcha

Abstract

The objective of the study was to determine anesthetic success of intraosseous injection for supplemental anesthesia in impacted lower third molar surgery by using 4% articaine with epinephrine 1 : 200,000. The heart rate effect and pain during injection were also evaluated. The clinical-based, quasi-experimental study was conducted in 36 patients who experienced discomfort or pain during the process of bone removal and/or tooth sectioning in lower third molar surgery received intraosseous injection using 4% articaine with 1 : 200,000 epinephrine, 0.6-0.9 ml in 30 seconds. The anesthetic success was evaluated by absence of pain during bone removal and tooth sectioning until complete tooth removal. The heart rate effect was measured by pulse oximeter before injection and in 1-minute intervals for 5 minutes. The pain during injection was recorded using verbal numerical rating scale. For the results, the anesthetic success of intra-osseous injection for supplemental anesthesia was over 90% (binomial test; p = 0.289). The heart rate was maximally increased in the first minute (mean = 4.24 ± 9.30%) after injection. The median and interquartile range of verbal numerical rating scale of pain during injection were 2 and 3.5, respectively. For conclusion, the intraosseous injection is an advantageous anesthetic technique. It can be used as a supplemental injection to conventional inferior alveolar nerve block for impacted mandibular third molar surgery.

Article Details

How to Cite
1.
Kanjana Singkharotai, Rapeeporn Malungpaishrope, Vanutsanun Theprod, Kanitha Pajonklaew, Khemjira Ummaralikit, Rawisara Pantien, et al. The effectiveness of intraosseous injection for supplemental anesthesia in impacted lower third molar surgery. Thai J. Oral Maxillofac. Surg. [Internet]. 2026 Sep. 9 [cited 2026 Nov. 1];35(2):90-8. Available from: https://he02.tci-thaijo.org/index.php/thaijoms/article/view/284824
Section
Original Articles

References

Kaufman E, Weinstein P, Milgrom P. Difficulties in achieving local anesthesia. J Am Dent Assoc. 1984;108:205-8.

Prohić S, Sulejmanagić H, Secić S. The efficacy of supplemental intraosseous anesthesia after insufficient mandibular block. Bosn J Basic Med Sci. 2005;5:57-60.

Meechan JG. How to overcome failed local anesthesia. Br Dent J. 1999;186:15-20.

Sareen J. Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment. Can J Psychiatry. 2014;59:460-7

Razavian H, Kazemi S, Khazaei S, Jahromi MZ. X-tip intraosseous injection system as a primary anesthesia for irreversible pulpitis of posterior mandibular teeth: a randomized clinical trial. Dent Res J (Isfahan). 2013;10:210-3.

Malamed SF. Handbook of local anesthesia. 7th ed. St. Louis: Mosby; 2015.

Coggins R, Reader A, Nist R, Beck M, Meyers WJ. Anesthetic efficacy of the intraosseous injection in maxillary and mandibular teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81:634-41.

Dunbar D, Reader A, Nist R, Beck M, Meyers WJ. Anesthetic efficacy of the intraosseous injection after an inferior alveolar nerve block. J Endod. 1996;22:481-6.

Arakeri G, Sagoo MG, Brennan PA. Neurovascular plexus theory for “escape pain phenomenon” in lower third molar surgery. Plast Aesthet Res. 2015;2:107-10.

Potočnik I, Bajrović F. Failure of inferior alveolar nerve block in endodontics. Endod Dent Traumatol. 1999;15:247-51.

Guglielmo A, Reader A, Nist R, Beck M, Weaver J. Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1 : 20,000 levonordefrin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:284-93.

Sovatdy S, Vorakulpipat C, Kiattavorncharoen S, Saeng-sirinavin C, Wongsirichat N. Inferior alveolar nerve block by intraosseous injection with Quicksleeper® at the retromolar area in mandibular third molar surgery. J Dent Anesth Pain Med. 2018;18:339-47.

Farhad A, Razavian H, Shafiee M. Effect of intraosseous injection versus inferior alveolar nerve block as primary pulpal anaesthesia of mandibular posterior teeth with symptomatic irreversible pulpitis: a prospective randomized clinical trial. Acta Odontol Scand. 2018;76:442-7.

Lilienthal B, Reynolds A. Cardiovascular responses to intraosseous injections containing catecholamines. Oral Surg Oral Med Oral Pathol. 1975;40:574-83.

Replogle K, Reader A, Nist R, Beck M, Weaver J, Meyers WJ. Cardiovascular effects of intraosseous injections of 2 percent lidocaine with 1 : 100,000 epinephrine and 3 percent mepivacaine. J Am Dent Assoc. 1999;130:649-57.

Pereira LAP, Groppo FC, de Cássia Bergamaschi C, Meechan JG, Ramacciato JC, Motta RHL, et al. Articaine (4%) with epinephrine (1 : 100,000 or 1: 200,000) in intraosseous injections in symptomatic irreversible pulpitis of mandibular molars: anesthetic efficacy and cardiovascular effects.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116: e85-91.

Susi L, Reader A, Nusstein J, Beck M, Weaver J, Drum M. Heart rate effects of intraosseous injections using slow and fast rates of anesthetic solution deposition. Anesth Prog. 2008;55:9-15.

Sivanmalai S, Anamalai S, Kumar S, Prince CN, Chandrakala, Thanqaswamy V. Pharmacodynamic responses of exogenous epinephrine during mandibular third molar surgery. J Pharm Bioallied Sci. 2012;4:390-3.

Liau FL, Kok SH, Lee JJ, Kuo RC, Hwang CR, Yang PJ, et al. Cardiovascular influence of dental anxiety during local anesthesia for tooth extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:16-26.

Kiattavorncharoen S, Manosuthi P, Wongsirichat N, Boonsiriseth K. The anesthesia efficacy of intraosseous injection with QuickSleeper® and conventional injection in the lower third molar surgery. M Dent J. 2013;33:139-42.