Cryotherapy versus salicylic acid for plantar warts: a systematic review


  • Farpratan Pongpanich
  • Thitiphong Chaikasemsakun
  • Natchaya Boonsarn



To identify the efficacy of cryotherapy and salicylic acid for treating plantar warts



Three independent reviewers systematically searched through electronic databases including  Cochrane library, Pubmed, Trip Database and Scopus. We also sought for additional studies using a hand searching to explore other unidentified studies on the databases to identify all relevant randomized controlled trials comparing cryotherapy to topical salicylic acid in term of clearance of plantar warts.



We identified and included two randomized controlled trials with 309 participants with plantar warts.The clearance of plantar warts at 3 months was interpreted that using cryotherapy was no statistically significant difference from using topical salicylic acid (RR 0.94; 95% CI 0.51 to 1.49, fixed-effect model, I2=0) and at 6 months (RR 1.07; 95% CI, 0.79 to 1.46, fixed-effect model, I2=0).



Clearance of plantar warts were not different between using cryotherapy and topical salicylic acid at 3 and 6 months.



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How to Cite

Pongpanich, F., Chaikasemsakun, T., & Boonsarn, N. (2019). Cryotherapy versus salicylic acid for plantar warts: a systematic review. The Clinical Academia, 43(2), 54–64. Retrieved from