Abnormal versus normal neuroimaging in acute infectious encephalitis and mortality
Abstract
BACKGROUND
Acute infectious encephalitis causes abnormal neuroimaging from computed tomography (CT) scan or magnetic resonance imaging (MRI) and its fatality is approximately up to 30% of cases.
METHODS
We conducted the retrospective cohort study by using International Classification of Diseases (ICD) 10 A80-A89 and G04 from Khon Kaen Hospital database, including medical record of patients that was preliminarily diagnosed as acute infectious encephalitis and hospitalized at Khon Kaen Hospital from January 2011 to May 2017 to compare abnormal neuroimaging and normal neuroimaging from CT scan or MRI. The primary outcome was death. The secondary outcomes were seizures, status epilepticus, mechanical ventilation usage, nosocomial infection, intensive care unit (ICU) admission, length of ICU admission and cardiac arrest.
RESULTS
In a total of 376 patients with acute infectious encephalitis were included and divided into 2 groups; 158 patients with abnormal neuroimaging and 218 patients with normal neuroimaging. Characteristics of two group were similar. Risk of mortality of those with or without abnormal neuroimaging from CT scan or MRI was not significantly different (hazard ratio (HR), 0.97; 95% confidence interval (CI), 0.67 to 1.40).
CONCLUSION
In current retrospective cohort showed no significantly different of risk of mortality between abnormal and normal neuroimaging from CT scan or MRI in patients with acute infectious encephalitis.
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