Helical tomotherapy planning for total marrow irradiation
Keywords:
Total marrow irradiation, Helical Tomotherapy, Dose verification, Hematologic Malignancy, OSLAbstract
OBJECTIVE
To evaluate plan quality of helical tomotherapy (HT) planning for total marrow irradiation (TMI) in rando phantom then verify dose by optically stimulated luminescence (OSL).
METHODS
Helical tomotherapy treatment planning for TMI in rando phantom was performed. Target areas included cranium bone, spine, pelvis, sternum, and ribs with expanded margin 5.00 mm for planning target volume (PTV). Organs at risk (OARs) for radiation were right eye, left eye, right lung, left lung, liver, right kidney, left kidney, heart, brain, and bowel. Prescribe dose for volume 95% (D95) of PTV≥12.00 Gy in 6 fractions. Dose verification by OSL in rando phantom position at the spine, sternum, and both lungs.
RESULTS
From TMI planning the D95 of PTV was 12.06 Gy and median dose (D50) of right eye, left eye, right lung, left lung, liver, right kidney, left kidney, heart, brain, and bowel were 7.09 Gy 5.23 Gy, 5.14 Gy, 5.94 Gy, 6.01 Gy, 5.97 Gy, 6.22 Gy, 5.12 Gy, 7.44 Gy, 10.03, and 7.09 Gy respectively. Results from the dose verification, % dose differences from planning compared with OSL dose at spine, sternum, right lung, and left lung were -5.54%, -4.19%, 0.08%, and -0.37% respectively.
CONCLUSION
Helical tomotherapy planning for TMI achieves target coverage of PTV and can reduce mean dose of OARs to 57.33% of prescribed dose. The dose verification of tomotherapy planning by OSL is convenient and high precision by mean dose difference 3.48%.
References
Hematologic Malignancies (Association of Community Cancer Centers) [Internet].[search 31 July 2020]. https://www.accc-cancer.org/home/learn/cancer-types/hematologic-malignancies
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