Basic calculations for renal function assessment in nuclear medicine techniques

Authors

  • Chanan Sukprakun Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, 10330
  • Tawatchai Chaiwatanarat Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330

Abstract

In this review article, the authors give basic calculations for renal function assessment in nuclear medicine techniques including evaluation of renal clearance measured by urine and plasma sampling, plasma sampling only, or renal scintigraphy with Patlak-Rutland method and integral method. Furthermore, there are calculations of renal transit time, renal output efficiency and normalized residual activity.

References

1. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260-72.
2. Ong-Ajyooth L, Vareesangthip K, Khonputsa P, Aekplakorn W. Prevalence of chronic kidney disease in Thai adults: a national health survey. BMC Nephrol. 2009;10:35.
3. Bailey D, Humm J, Todd-Pokropek A, Aswegen Av. Nuclear Medicine Physics: A Handbook for Teachers and Students. Endorsed by: American Association of Physicists in Medicine (AAPM), Asia–Oceania Federation of Organizations for Medical Physics (AFOMP), Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM), European Federation of Organisations for Medical Physics (EFOMP), Federation of African Medical Physics Organisations (FAMPO), World Federation of Nuclear Medicine and Biology (WFNMB). 2014.
4. Prigent A, Cosgriff P, Gates GF, Granerus G, Fine EJ, Itoh K, et al. Consensus report on quality control of quantitative measurements of renal function obtained from the renogram: International Consensus Committee from the Scientific Committee of Radionuclides in Nephrourology. Semin Nucl Med. 1999;29(2):146-59.
5. Peters AM. Graphical analysis of dynamic data: the Patlak-Rutland plot. Nucl Med Commun. 1994;15(9):669-72.
6. Gates GF. Split renal function testing using Tc-99m DTPA. A rapid technique for determining differential glomerular filtration. Clinical nuclear medicine. 1983;8(9):400-7.
7. Sontrapornpol T, Chaiwatanarat T, Kawinthammasak C, Kamklon N, Rattanamonrot R. Kidney depth calculation by anterior and posterior renal scintigraphy using attenuation–related techniques. Chulalongkorn Medical Journal. 2017;61(4):425-38.
8. Durand E, Blaufox MD, Britton KE, Carlsen O, Cosgriff P, Fine E, et al. International Scientific Committee of Radionuclides in Nephrourology (ISCORN) consensus on renal transit time measurements. Semin Nucl Med. 2008;38(1):82-102.
9. Fleming JS, Kemp PM. A comparison of deconvolution and the Patlak-Rutland plot in renography analysis. J Nucl Med. 1999;40(9):1503-7.
10. Brown SC, Upsdell SM, O’Reilly PH. The importance of renal function in the interpretation of diuresis renography. Br J Urol. 1992;69(2):121-5.
11. Chaiwatanarat T, Laorpatanaskul S, Poshyachinda M, Boonvisut S, Buachum V, Krisanachinda A, et al. Deconvolution analysis of renal blood flow: evaluation of postrenal transplant complications. J Nucl Med. 1994;35(11):1792-6.
12. P.H. O’Reilly PH, Shields RA, Testa HJ. Nuclear Medicine in Urology And Nephrology. 2nd London: Butterworth & Co.; 1986 13. Lawson RS. Application of mathematical methods in dynamic nuclear medicine studies. Phys Med Biol. 1999;44(4):R57-98.
14. Chaiwatanarat T, Padhy AK, Bomanji JB, Nimmon CC, Sonmezoglu K, Britton KE. Validation of renal output efficiency as an objective quantitative parameter in the evaluation of upper urinary tract obstruction. J Nucl Med. 1993;34(5):845-8.
15. Piepsz A, Tondeur M, Ham H. NORA: a simple and reliable parameter for estimating renal output with or without frusemide challenge. Nucl Med Commun. 2000;21(4):317-23.
16. Piepsz A, Kuyvenhoven JD, Tondeur M, Ham H. Normalized residual activity: usual values and robustness of the method. J Nucl Med. 2002;43(1):33-8.

Downloads

Published

2022-12-31

How to Cite

1.
Sukprakun C, Chaiwatanarat T. Basic calculations for renal function assessment in nuclear medicine techniques. Thai J Rad Tech [Internet]. 2022 Dec. 31 [cited 2024 Jul. 26];47(1):23-34. Available from: https://he02.tci-thaijo.org/index.php/tjrt/article/view/254913

Issue

Section

Review articles