Factors associated with Extended-spectrum -Lactamase Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Infection among hospitals in Nakhon Phanom province
Keywords:
Extended-spectrum -Lactamase, Escherichia coli, Klebsiella pneumoniae, Bloodstream infectionAbstract
The aim of this study was to investigate factors associated with Extended-spectrum -Lactamase
Producing Escherichia coli and Klebsiella pneumoniae (ESBLs) bloodstream infection among hospitals
in Nakhon Phanom Province. The study design was a Case-Control Study and data collected from
hospital base in Nakhon Phanom province during 1 Jan. 2014 to 31 Dec. 2014. Participants included
89 patients infected with ESBLs and 89 patients infected with non-ESBLs. The descriptive statistics,
simple logistic regression and multiple logistic regression were using to evaluate factors potentially
associated with ESBLs infection. On multivariate analysis, four predictors associated with ESBL-producing
pathogens bloodstream infection in the hospitals of Nakhon Phanom Province included male sex
(ORadj = 2.43, 95% CI: 1.23-4.79), chronic kidney disease (ORadj = 3.86, 95% CI: 1.44-10.34),
prolong admission 7 days (ORadj = 2.10, 95% CI: 1.08-4.08) and prior cephalosporins therapy
(ORadj = 4.40, 95% CI: 1.93-10.02). This study demonstrates several risks factors associated
with ESBL-producing E. coli or K. pneumoniae infection occurring during treatment in hospital.
The cooperation of healthcare provider’s response for surveillance and control of infections in hospital
can help to reduce the incidence of ESBL-producing pathogens in patients.
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