The Efficacy of Chemo-Cooling Gloves in Preventing Nail Toxicity among Thai Women Undergoing Chemotherapy: A Quasi-experimental Study

Authors

  • Kantaporn Yodchai Faculty of Nursing, Prince of Songkla University, Songkhla, Thailand.
  • Sakorn Hubjaroen Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
  • Ketsaree Maneekrong Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
  • Nattapon Uthaipan Faculty of Engineering, Prince of Songkla University, Songkhla, Thailand.

DOI:

https://doi.org/10.60099/prijnr.2024.267762

Keywords:

Breast cancer, Chemotherapy, Cryotherapy, Nail toxicity, Satisfaction

Abstract

Cryotherapy is widely used in health contexts, including first aid, treating acute musculoskeletal injuries and women undergoing chemotherapy. Studies have shown that frozen gloves can help reduce nail toxicity for women undergoing chemotherapy. Nail toxicity is a common issue among people undergoing chemotherapy, causing disfigurement and pain. Although cooling gloves have been shown to reduce nail toxicity, the range of temperatures used remains unclear, often resulting in discomfort. In this innovative study, we used a quasi-experimental, two group pretest-posttest design to evaluate the effectiveness of Chemo-Cooling Gloves developed by the researchers to help prevent nail toxicity. We assessed satisfaction with the gloves among 27 Thai women undergoing chemotherapy who were purposively recruited according to the inclusion criteria from a chemotherapy center of a university-affiliated hospital in a southern region of Thailand. Participants underwent a regimen of cyclophosphamide in combination with doxorubicin and 5-fluorouracil every 21 days for six cycles. Each participant served as their own control, wearing the cooling glove on the one hand randomly selected, while the other hand remained unprotected and acted as the control. Data were collected using a demographic questionnaire, the Common Terminology Criteria for Adverse Events version 3.0, and the Chemo-Cooling Gloves Satisfaction Questionnaire. Data analysis utilized descriptive statistics and Cochran’s Q test.

The results revealed that nail toxicity was significantly lower in the protected hand than in the control hand during cycles 2 to 3 and 2 to 4, but no significant difference between the two hands during cycles 2 to 5 and 2 to 6. Overall satisfaction with the Chemo-Cooling Gloves was at the highest level. The use of frozen gloves aligns with evidence-based practice, as supported by our study. Nurses need to be trained in the proper use and application of the gloves and educate patients on the benefits and correct usage to maximize comfort and efficacy. By incorporating the Chemo-Cooling Gloves into routine practice, nurses can help improve patient adherence to chemotherapy regimens and potentially enhance treatment outcomes.

References

World Health Organization. Breast cancer [Internet]. 2024 Mar 13 [cited 2024 Apr 6]. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer

Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, et al. Breast cancer statistics 2022. CA Cancer J Clin. 2022;72:524-41. doi: 10.3322/caac.21754. DOI: https://doi.org/10.3322/caac.21754

Alessandrini A, Starace M, Cerè G, Brandi N, Piraccini BM. Management and outcome of taxane-induced nail side effects: experience of 79 patients from a single center. Skin Appendage Disord. 2019;5(5):276-82. doi: 10.1159/000497824. DOI: https://doi.org/10.1159/000497824

Burguin A, Diorio C, Durocher F. Breast cancer treatments: updates and new challenges. J Pers Med. 2021;11(8):808. doi:10.3390/jpm11080808. DOI: https://doi.org/10.3390/jpm11080808

Emvalomati A, Oflidou V, Papageorgiou C, Kemanetzi C, Giannouli M, Kalloniati E, et al. Narrative review of drug-associated nail toxicities in oncologic patients. Dermatol Pract Concept. 2023;13(1): e2023064. doi: 10.5826/dpc.1301a64. DOI: https://doi.org/10.5826/dpc.1301a64

Marks D, Qureshi A, Friedman A. Evaluation of prevention interventions for taxane-induced dermatologic adverse events: a systematic review. JAMA Dermatol. 2018;154(12); 1465-72. doi: 10.1001/jamadermatol.2018.3465. DOI: https://doi.org/10.1001/jamadermatol.2018.3465

Zhai J, Wu Y, Ma F, Kaklamani V, Xu B. Advances in medical treatment of breast cancer in 2022. Cancer Innov. 2023;2(1):1-17. doi: 10.1002/cai2.46. DOI: https://doi.org/10.1002/cai2.46

Mittal S, Khunger N, Kataria SP. Nail changes with chemotherapeutic agents and targeted therapies. Indian Dermatol. Online J. 2022;13(1):13-22. doi:10.4103/ idoj.IDOJ_801_20. DOI: https://doi.org/10.4103/idoj.IDOJ_801_20

National Insurance Office. Guidelines for requesting public health services for adult cancer cases, 2023 [Internet]. 3202 [cited 2024 Apr 10]. Available from: https://www.nhso.go.th/downloads/228 (in Thai).

Morrison A, Marshall-McKenna R, McFadyen AK, Hutchison C, Rice AM, Stirling L, et al. A randomised controlled trial of interventions for taxane-induced nail toxicity in women with early breast cancer. Sci Rep. 2022; 12(1):11575. doi: 10.1038/s41598-022-13327-6. DOI: https://doi.org/10.1038/s41598-022-13327-6

Alshari O, Aleshawi A, Al Sharie A H, Msameh A, Al-Omari I, Msameh R, et al. The effect of nail lacquer on taxane-induced nail changes in women with breast cancer. Breast Cancer (Auckl). 2020;14:1178223420929702. doi: 10.1177/ 1178223420929702. DOI: https://doi.org/10.1177/1178223420929702

Coolbrandt A, Vancoille, K, Dejaeger E, Peeters H, Laenen A, Neven P, et al. Preventing taxane-related peripheral neuropathy, pain and nail toxicity: a prospective self-controlled trial comparing hilotherapy with frozen gloves in early breast cancer. Breast Cancer Res Treat. 2022;192(2):293–301. doi: 10.1007/s10549-021-06477-0. DOI: https://doi.org/10.1007/s10549-021-06477-0

Dodd M, Janson S, Facione N, Faucett J, Froelicher ES, Humphreys J, et al. Advancing the science of symptom management. J Adv Nurs. 2001;33(5):668-76. doi: 10.1046/j.1365-2648.2001.01697.x. DOI: https://doi.org/10.1046/j.1365-2648.2001.01697.x

National Cancer Institute. Common terminology criteria for adverse events v3.0 (CTCAE). 2006 [cited 2020 Mar 26]. Available from: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcaev3.pdf

Thomas R, Williams M, Cauchi M, Berkovitz S, Smith SA. A double-blind, randomised trial of a polyphenolic-rich nail bed balm for chemotherapy-induced onycholysis: the UK polybalm study. Breast Cancer Res Treat. 2018;171(1): 103–10. doi:10.1007/s10549-018-4788-9. DOI: https://doi.org/10.1007/s10549-018-4788-9

Coolbrandt A, Tobback H, Govaerts R, Vandezande L, Vinckx M, Laenen A, et al. A randomized controlled trial of hand/foot-cooling by hilotherapy to prevent oxaliplatin-related peripheral neuropathy in patients with malignancies of the digestive system. ESMO Open. 2023;8(2):101205. doi: 10.1016/j.esmoop.2023.101205. DOI: https://doi.org/10.1016/j.esmoop.2023.101205

Huang KL, Lin KY, Huang TW, Loh EW, Hua YM, Su HC, et al. Prophylactic management for taxane-induced nail toxicity: a systematic review and meta-analysis. Eur J Cancer Care (Engl). 2019;28(5):e13118. doi:10.1111/ecc.13118. DOI: https://doi.org/10.1111/ecc.13118

Salzmann M, Marmé F, Hassel JC. Prophylaxis and management of skin toxicities. Breast Care (Basel). 2019; 14(2):72–7. doi:10.1159/000497232. DOI: https://doi.org/10.1159/000497232

Mazzega-Fabbro C, Polesel J, Spazzapan S, Meneghetti L, Montagner D, Tabaro G, et al. Mild cryotherapy for prevention of paclitaxel-induced nail toxicity in breast cancer patients: a phase II single-arm clinical trial. Clin Breast Cancer. 2023;23(4):447-53. doi: 10.1016/j. clbc.2023.03.004. DOI: https://doi.org/10.1016/j.clbc.2023.03.004

Sakurai M, Todaka K, Takada N, Kamigaki S, Anami S, Shikata A. Multicenter phase II study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity for the breast cancer patients (Kinki Multidisciplinary Breast Oncology Group: KMBOG-0605). Cancer Res. 2009;69(2 Suppl):4093. doi: 10.1158/0008-5472.SABCS-4093. DOI: https://doi.org/10.1158/0008-5472.SABCS-4093

Can G, Aydiner A, Cavdar I. Taxane-induced nail changes: predictors and efficacy of the use of frozen gloves and socks in the prevention of nail toxicity. Eur J Oncol Nurs. 2012; 16(3):270-5. doi: 10.1016/j.ejon.2011.06.007. DOI: https://doi.org/10.1016/j.ejon.2011.06.007

Ishiguro H, Takashima S, Yoshimura K, Yano I, Yamamoto T, Niimi M, et al. Degree of freezing does not affect efficacy of frozen gloves for prevention of docetaxel-induced nail toxicity in breast cancer patients. Support Care Cancer. 2012;20(9):2017-24. doi: 10.1007/s00520-011- 1308-4. DOI: https://doi.org/10.1007/s00520-011-1308-4

Ferreira MN, Ramseier JY, Leventhal JS. Dermatologic conditions in women receiving systemic cancer therapy. Int J Womens Dermatol. 2019;5(5):285-307. doi: 10.1016/j.ijwd.2019.10.003. DOI: https://doi.org/10.1016/j.ijwd.2019.10.003

Yodchai K, Thasaneesuwan S, Promlek K, Hubjaroen S, Maneekrong K, Thongprom C, et al. The effectiveness of cryotherapy with natural rubber form gloves on skin surface temperature and satisfaction in healthy adults: prototype testing. JRN-MHS. 2023;43(3):78-91. Available from: https://he02.tci-thaijo.org/index.php/nur-psu/article/view/262558/181726 (in Thai).

Cohen J, Statistical power analysis for the behavioral sciences. New York, Routledge Academic; 1988.

McCarthy AL, Shaban RZ, Gillespie K, Vick J. Cryotherapy for docetaxel-induced hand and nail toxicity: randomised control trial. Support Care Cancer. 2014;22(5):1375-83. doi: 10.1007/s00520-013-2095-x.

Leppink J, O’Sullivan P, Winston K. Effect size-large, medium, and small. Perspect Med Educ. 2016;5(6):347-9. doi: 10.1007/s40037-016-0308y. DOI: https://doi.org/10.1007/S40037-016-0308-Y

Petersen I, Douglas I, Whitaker H. Self controlled case series method: an alternative to standard epidemiological study designs. BMJ. 2016;354:i4515. doi: 10.1136/bmi.j4515. DOI: https://doi.org/10.1136/bmj.i4515

Brislin RW. Back-translation for cross-cultural research. J Cross-Cult Psychol. 1970;1(3):185-216. doi:10.1177/ 135910457000100301. DOI: https://doi.org/10.1177/135910457000100301

Laha W, Hiruntrakul A, Ninprapan A .The satisfaction of user in the isometric leg strength dynamometer in setting position for field test. KKU Res J (GS). 2018;18(2):32- 43. Available from: https://ph02.tci-thaijo.org/index. php/gskku/article/view/127074/95917 (in Thai).

Scotté F, Banu E, Medioni J, Levy E, Ebenezer C, Marsan S, et al. Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer. 2008;112(7):1625-31. doi: 10.1002/cncr.23333. DOI: https://doi.org/10.1002/cncr.23333

McCarthy AL, Shaban RZ, Gillespie K, Vick J. Cryotherapy for docetaxel-induced hand and nail toxicity: randomised control trial. Support Care Cancer. 2014;22(5):1375- 83. doi: 10.1007/s00520-013-2095-x. DOI: https://doi.org/10.1007/s00520-013-2095-x

Peyton L, Fischer-Cartlidge E. Extremity cooling: a synthesis of cryotherapy interventions to reduce peripheral neuropathy and nail changes from taxane-based chemotherapy. Clin J Oncol Nurs. 2019;23(5):522-8. doi: 10.1188/ 19.CJON.522-528. DOI: https://doi.org/10.1188/19.CJON.522-528

Downloads

Published

2024-06-12

How to Cite

1.
Yodchai K, Hubjaroen S, Maneekrong K, Uthaipan N. The Efficacy of Chemo-Cooling Gloves in Preventing Nail Toxicity among Thai Women Undergoing Chemotherapy: A Quasi-experimental Study. PRIJNR [Internet]. 2024 Jun. 12 [cited 2024 Oct. 6];28(3):619-31. Available from: https://he02.tci-thaijo.org/index.php/PRIJNR/article/view/267762