Primary Brain Tumors in Thais: Symptom Experience and Predicting Factors

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Natthacha Chiannilkulchai
Orapan Thosingha
Usavadee Asdornwised
Prasert Sarnvivad
Chukiat Viwatwongkasem

Abstract

            This longitudinal repeated-measure study aimed to evaluate the occurrence, severity, and interference of the common symptoms and their predicting factors of Thais with primary brain tumors before, during, and at the end of radiotherapy. One hundred and sixteen adult and older participants were recruited from three hospitals residing in the metropolitan area of Bangkok. The measures used were a demographic and medical record form, the Mini-Mental State Examination and the M.D Anderson Symptom Inventory-Brain Tumor.
             Results revealed that the most common symptoms found in various occurrence and severity dimensions were: fatigue, drowsiness, sleep disturbances, difficulty remembering, and change in appearance. Fatigue and sleep disturbance were the most common symptoms occurring and their severity existed from the beginning to end of radiotherapy. The type of radiotherapy predicted the occurrence and the severity of fatigue, sleep disturbance, difficulty remembering, change in appearance, and feeling upset. Tumor laterality predicted the severity of fatigue, difficulty remembering, change in appearance, pain, and feeling upset, whereas, tumor location predicted only the severity of drowsiness, difficulty remembering and visual impairment. Tumor type predicted the severity of most common symptoms. It is recommended that nurses should be aware of these symptoms in order to facilitate patients to obtain smooth transition during radiotherapy. Nurses who work in radiotherapy clinics and in wards with patients with brain tumours receiving this treatment, should be trained and encouraged to use the scales to assess patients’ symptoms. A nursing practice guideline needs to be developed to care for patients receiving radiotherapy, emphasizing symptom assessment and management, and follow up care as well as evaluating patients’ clinical outcomes.

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1.
Chiannilkulchai N, Thosingha O, Asdornwised U, Sarnvivad P, Viwatwongkasem C. Primary Brain Tumors in Thais: Symptom Experience and Predicting Factors. PRIJNR [Internet]. 2016 Oct. 31 [cited 2022 Oct. 5];20(4):275-92. Available from: https://he02.tci-thaijo.org/index.php/PRIJNR/article/view/45045
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References

1. Lin L, Chiang H-H, Acquaye AA, Vera-Bolanos E, Gilbert MR, Armstrong TS. Uncertainty, mood states, and symptom distress in patients with primary brain tumors. Cancer. 2013;119(15):2796-806.

2. Scoccianti S, Detti B, Cipressi S, Iannalfi A, Franzese C, Biti G. Changes in neurocognitive functioning and quality of life in adult patients with brain tumors treated with radiotherapy. J Neurooncol. 2012;108(2):291-308.

3. Patel TR, Yu JB, Piepmeier JM. Role of neurosurgery and radiation therapy in the management of brain tumors. Hematol Oncol Clin North Am. 2012;26(4):757-77.

4. Huang T, Mueller S, Rutkowski MJ, Han SJ, Bloch O, Barani IJ, et al. Multidisciplinary care of patients with brain tumors. Surg Oncol Clin N Am. 2013;22(2):161-78.

5. Zucchella C, Bartolo M, Di Lorenzo C, Villani V, Pace A. Cognitive impairment in primary brain tumors outpatients: A prospective cross-sectional survey. J Neurooncol. 2013; 112:455–60.

6. Van Nieuwenhuizen D, Ambachtsheer N, Heimans JJ, Reijneveld JC, Peerdeman SM, Klein M. Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas. J Neurooncol. 2013;113(3):433-40.

7. Suh JH, Chao ST, Murphy ES, Weil RJ. Pituitary tumors and craniopharyngiomas In: Tepper, Leonard L, Gunderson, JE, Clinical Radiation Oncology 4th ed. Philadelphia: Elsevier; 2016. p. 502-20.e4.

8. Dodd MJ, Janson SL, Facione N, Faucett J, Froelicher ES, Humphreys J, et al. Advancing the science of symptom management. J Adv Nurs. 2001;33(5):668-76.

9. Humphreys J, Lee KA, Carrieri-Kohlman V, Puntillo K, Faucett J, Janson S, et al. Theory of Symptom Management. In: Smith MJ, Liehr PR, editors. Middle range theory for nursing. 2nd ed. New York: Springer Publishing Company; 2008. p. 145-58.

10. Haghighi N, Seely A, Paul E, Dally M. Hypofractionated stereotactic radiotherapy for benign intracranial tumours of the cavernous sinus. J Clin Neurosci. 2015;22(9):1450-5.

11. Mattavelli G, Casarotti A, Forgiarini M, Riva M, Bello L, Papagno C. Decision-making abilities in patients with frontal low-grade glioma. J Neurooncol. 2012;110:59–67.

12. Emanuele B, Santini B, Talacchi A, Gerosa M, Savazzi S. Pre- and post-operative assessment of visuo-spatial functions in right hemisphere tumour patients: A pilot study. J Neurooncol. 2012;108(2):261-7.

13. Ren L, Ryu S. Radiation therapy: Intensity-Modulated Radiotherapy, Cyberknife, Gamma Knife, and Proton Beam. In: Dupuy ED, Fong Y, McMullen NW, editors. Image-Guided Cancer Therapy: A Multidisciplinary Approach. New York, NY: Springer New York; 2013. p. 137-46.

14. Platten M, Wick W. Chapter 5 - Blood–brain barrier and brain edema. In: Michael J. Aminoff FB, Dick FS, editors. Handb Clin Neurol. Volume 104: Elsevier; 2012. p. 53-62.

15. Cámara Gómez R. Non-functioning pituitary tumors: 2012 update. Endocrinología y Nutrición (English Edition). 2014;61(3):160-70.

16. Powell C, Guerrero D, Sardell S, Cumins S, Wharram B, Traish D, et al. Somnolence syndrome in patients receiving radical radiotherapy for primary brain tumours: A prospective study. Radiother Oncol. 2011;100(1):131-6.

17. Diaz AZ, Choi M. Radiation-associated toxicities in the treatment of high-grade gliomas. Semin Oncol. 2014; 41(4):532-40.

18. Sumdaengrit B, Hanucharurnkul S, Dodd MJ, Wilailak S, Vorapongsathorn T, Pongthavornkamol K. Symptom experience and self-care among Thai women with cervical cancer. Pacific Rim of J Nurs Res 2010;14(3):203-18.

19. Adeberg S, Hartmann C, Welzel T, Rieken S, Habermehl D, von Deimling A, et al. Long-term outcome after radiotherapy in patients with atypical and malignant meningiomas—Clinical results in 85 patients treated in a single institution leading to optimized guidelines for early radiation therapy. Int J Radiat Oncol Biol Phys. 2012;83(3):859-64.

20. Klein M. Neurocognitive functioning in adult WHO grade II gliomas: Impact of old and new treatment modalities. Neuro Oncol. 2012;14(suppl 4):iv17-iv24.

21. Reddy K, Gaspar L, Kavanagh B, Waziri A, Damek D, Ney D, et al. Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide. J Neurooncol. 2013;114(1):111-6.

22. Maclean J, Fersht N, Bremner F, Stacey C, Sivabalasingham S, Short S. Meningioma causing visual impairment: Outcomes and toxicity after intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2013;85(4): e179-e86.

23. Macartney G, VanDenKerkhof E, Harrison MB, Stacey D. Symptom experience and quality of life in pediatric brain tumor survivors: A cross-sectional study. J Pain Symptom Manage. 2014;48(5):957-67.

24. Armstrong TS, Vera-Bolanos E, Gning I, Acquaye A, Gilbert MR, Cleeland C, et al. The impact of symptom interference using the MD Anderson Symptom InventoryBrain Tumor Module (MDASI-BT) on prediction of recurrence in primary brain tumor patients. Cancer. 2011; 117(14):3222–8.

25. Henzel M, Fokas E, Sitter H, Wittig A, Engenhart-Cabillic R. Quality of life after stereotactic radiotherapy for meningioma: A prospective non-randomized study. J Neurooncol. 2013;113(1):135-41.

26. Tooze A, Hiles CL, Sheehan JP. Neurocognitive changes in pituitary adenoma patients after gamma knife radiosurgery: A preliminary study. World Neurosurg. 2012;78(1–2): 122-8.

27. Armstrong TS, Vera-Bolanos E, Acquaye A, Gilbert, Mark R., Mendoza TR. Impact of recall period on primary brain tumor patients’ self-report of symptoms. Neurooncol Pract. 2014;1(2):55-63.

28. Walbert T, Mendoza T, Vera-Bolaños E, Acquaye A, Gilbert M, Armstrong T. Symptoms and socio-economic impact of ependymoma on adult patients: Results of the adult ependymoma outcomes project 2. J Neurooncol. 2014:1-8.

29. Park H, Kang H-C, Kim I, Park S-H, Kim D, Park C-K, et al. The role of adjuvant radiotherapy in atypical meningioma. J Neurooncol. 2013;115(2):241-7.

30. Holliday EB, Dieckmann NF, McDonald TL, Hung AY, Thomas Jr CR, Wood LJ. Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer: A prospective study. Radiother Oncol. 2016;118(1):105-11.

31. Welzel G, Fleckenstein K, Mai SK, Hermann B, KrausTiefenbacher U, Wenz F. Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors. Strahlenther Onkologie. 2008;184:647–54.

32. Ding D, Starke RM, Sheehan JP. Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and radiation therapy. J Neurooncol. 2013;117(3):445-57.

33. Soldà F, Wharram B, De Ieso PB, Bonner J, Ashley S, Brada M. Long-term efficacy of fractionated radiotherapy for benign meningiomas. Radiother Oncol. 2013;109(2): 330-4.

34. Dijkstra M, Nieuwenhuizen Dv, Stalpers LJA, Wumkes M, Waagemans M, Vandertop WP, et al. Late neurocognitive sequelae in patients with WHO grade I meningioma J Neurol Neurosurg Psychiatry. 2009;80:910–5.

35. Carlesimo G. Memory disorders in patients with cerebral tumors. J Neurooncol. 2012;108(2):253-6.

36. Lawrence YR, Wang M, Dicker AP, Andrews D, Curran WJ, Michalski JM, et al. Early toxicity predicts long-term survival in high-grade glioma. Br J Cancer. 2011;104(9): 1365-71.

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