Case Fatality Rate and Factors Associated with Deaths due to Septicemia in Damnoen Saduak Hospital, Ratchaburi Province
Keywords:
Case fatality rate, Risk factors, SepticemiaAbstract
A retrospective cohort study aimed to determine the case fatality rate of patients with sepsis and factors associated with deaths due to septicemia in Damnoen Saduak Hospital, Ratchaburi Province. The population was the inpatients diagnosed with sepsis who had positive blood cultures between January 1, 2020, and December 31, 2022. A total of 319 patients were collected. The research instrument was an individualized data collection to collect demographic, laboratory, and clinical outcomes. The data were analyzed using descriptive statistics and inferential statistics. Variables with statistical significance from comparative analyses were included in a binary logistic regression analysis to identify the factors associated with deaths and to determine these adjusted odds ratios, 95% confidence intervals and significance level at p-value <0.05
The 30-day case fatality rate was 29.15%. The factors associated with deaths in this cohort study were male gender (aOR: 2.46, 95% CI: 1.33-4.56), cancer (aOR: 5.62, 95% CI: 2.45-12.90), endotracheal intubation (aOR: 4.75, 95% CI: 2.22-10.17), serum creatinine level (aOR: 1.31, 95% CI: 1.09-1.57) and serum lactate level (aOR: 1.26, 95% CI: 1.13-1.41). The factors associated with reduced deaths were receipt of appropriate initial empirical antimicrobial therapy (aOR: 0.42, 95% CI: 0.22-0.77) and hemoglobin level (aOR: 0.84, 95% CI: 0.76-0.94).
Sepsis mortality remains high. The patients with factors associated with deaths should be immediately managed and appropriately assessed to reduce deaths.
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