Risk Factor of Recurrence Graves’ Disease after Treated with Anti-thyroid Drug in Damnoen Saduak Hospital

Abstract

This retrospective cohort study aims to evaluate risk factors influencing the recurrence of Graves' disease (GD) in patients following treatment with anti-thyroid drugs (ATD) at Damnoen Saduak hospital, Ratchaburi. Data were collected from the medical records of 110 patients. The research instrument were medical records using individual data records, laboratory results, treatment details, and outcomes. Statistical methods employed for data analysis included chi-square tests, independent t-tests, and logistic regression analysis. The findings indicated that:

The group of patients with recurrence of Graves' disease (GD) after treatment with antithyroid drugs was age, pre-treatment FT3, and FT4 levels, as well as the duration until reaching the minimum drug dose before cessation, were significantly different between patients experiencing GD recurrence post ATD treatment and those who achieved cure. Nevertheless, conducting logistic regression analysis considering the factors mentioned above, it was observed that as age increases, there is a significant reduction in disease recurrence.  A predictive equation was formulated to estimate recurrence probability, achieving an accuracy rate of 72.70%.

From this study, age affects the recurrence of the GD. Younger patients had more recurrence than older patients. Choosing a treatment method for patients with GD should use the drug as a consideration for the treatment modality.