Effects of L-theanine on Reducing Anxiety in Patients with Mild Cognitive Impairment at Suphanburi province
Keywords:
L-theanine, Anxiety, Anti-anxiety effect, Mild Cognitive ImpairmentAbstract
This randomized, double-blind, placebo-controlled trial aimed to determine the effect of L-theanine on anxiety symptoms in individuals with mild cognitive impairment (MCI). Twenty individuals diagnosed with mild cognitive impairment (MCI) were enrolled in the study. Randomly, 200 mg of L-theanine or a placebo was given to each participant. Before and 60 minutes after the intervention, the anxiety state was measured using the Stress-Trait Anxiety Inventory (STAI)-state. To assess the effects of anxiety, physiological indicators such as blood pressure and heart rate were also recorded before and an hour after the experiment. Descriptive data were analyzed using frequencies, percentage, mean, and standard deviation. Wilcoxon signed rank was applied to evaluate the parameters within groups to compare pre- and post-intervention, and the Mann-Whitney U test was applied to evaluate the mean difference between groups.
The results showed a significant decrease in STAI scores following the single dose of 200 mg of L-theanine administration (p=0.023). Systolic blood pressure was significantly lower following L-theanine administration (p=0.021), while diastolic blood pressure and heart rate did not significantly change. Our collective findings suggest that L-theanine could be a potential neutraceutical alternative for managing anxiety in individuals with mild cognitive impairment (MCI), emphasizing its therapeutic potential and potential benefits for cognitive well-being and overall quality of life in this population.
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