A Case Report of Febrile Ulceronecrotic Mucha-Habermann Disease in Thailand
Keywords:
Febrile ulceronecrotic Mucha-Habermann disease, tetracycline, cyclosporineAbstract
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by an acute onset of ulceronecrotic papules, rapidly coalescing into large necrotic ulcers and associated with high fever, severe systemic symptoms with a reported mortality rate approximately 20%. We reported a case of a 39-year-old man with a FUMHD and transaminitis. He was treated with prednisolone, tetracycline, dapsone, and narrowband UVB (NB-UVB) phototherapy without disease controlled. FUMHD has been reported with abnormally high serum levels of TNFα and cyclosporine is an immunosuppressive agent that suppresses interleukin-2 and TNFα production. The patient had favorable response after 3 months of cyclosporine therapy.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น
