Disseminated fusariosis in leukemia patient

Authors

  • Warittha Maitrisathit DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, PHRAMONGKUTKLAO HOSPITAL, BANGKOK
  • Vasin Vasikasin DIVISION OF INFECTIOUS DISEASES, DEPARTMENT OF MEDICINE, PHRAMONGKUTKLAO HOSPITAL, BANGKOK
  • Chutika Srisuttiyakorn DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, PHRAMONGKUTKLAO HOSPITAL, BANGKOK

Keywords:

Disseminated fusariosis, leukemia

Abstract

Disseminated fusariosis is an infection caused by Fusarium spp. that primarily affects patients with hematologic malignancies and hematopoietic stem cell transplant recipients.1 The infection typically involves pulmonary system and can lead to metastatic skin lesions. The portal of entry is the airway through inhalation of aerosols of fusarial conidia or direct skin penetration.2 We reported the refractory acute lymphocytic leukemia patient with disseminated fusariosis who presented with fever and characteristic skin lesions. He also had invasive pulmonary and muscle infection which can be identified by imagin.

References

1. Nucci M, Varon AG, Garnica M, et al. Increased incidence of invasive fusariosis with cutaneous portal of entry, Brazil. Emerg Infect Dis 2013; 19: 1567-72.

2. Girmenia C, Arcese W, MicozziA, Martino P, Bianco P, Morace G. Onychomycosis as a possible origin of disseminated Fusarium solani infection in a patient with severe aplastic anemia. Clin Infect Dis 1992; 14: 1167.

3. Nelson PE, Dignani MC, Anaissie EJ. Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev 1994; 7:479–504.

4. Nucci M, Anaissie E. Fusarium infections in immunocompromised patients. Clin Microbiol Rev 2007; 20: 695–704.

5.Anaissie EJ, Kuchar RT, Rex JH, et al. Fusariosis associated with pathogenic Fusarium species colonization of a hospital water system: a new paradigm for the epidemiology of opportunistic mold infections. Clin Infect Dis 2001; 33: 1871-8.

6. Nucci M, Anaissie EJ, Queiroz TF, et al. Outco me predictors of 84 patients with hematologic malignancies and Fusarium infection. Cancer 2003; 98: 315-9.

7. Nucci F, Nouér SA, Capone D, Anaissie E, Nucci M. Fusariosis. Semin Respir Crit Care Med 2015; 36: 706-14.

8. Matsuda T, Matsumoto T. Disseminated hyalohyphomycosis in a leukemic patient. Arch Dermatol 1986; 122: 1171-5.

9. King BA, Seropian S, Fox LP. Disseminated fusarium infection with muscle involvement. J Am Acad Dermatol 2011; 65: 235-7.

10. Hennequin C, Benkerrou M, Gaillard JL, Blanche S, Fraitag S. Role of granulocyte colony-stimulating factor in the management of infection with Fusarium oxysporum in a neutropenic child. Clin Infect Dis 1994; 18: 490-1.

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Published

2018-12-21

How to Cite

Maitrisathit, W., Vasikasin, V., & Srisuttiyakorn, C. (2018). Disseminated fusariosis in leukemia patient. Thai Journal of Dermatology, 34(4), 292–298. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/162836