Multicentric reticulohistiocytosis as a manifestation of reoccurrence of malignancy: a case report
Keywords:
multicentric reticulohistiocytosis, malignancyAbstract
Multicentric reticulohistiocytosis (MRH) is a rare, unknown etiologic, non-Langerhans cell histiocytosis, which is characterized by papulonodular skin lesions with destructive polyarthritis and may affect other visceral organs as a systemic disease. The association of MRH with malignancies has been reported up to 15-31% in various types of both solid and hematologic malignancies. We report a case of 62-year-old Thai female with clinical remission after treatment of left breast cancer two years ago, who presented with polyarthralgia preceding the gradual eruption of multiple tender cutaneous papules and nodules on face and extremities. Lesional skin biopsy from the right elbow showed a well-circumscribed nodular infiltration composed of multinucleated giant cells with eosinophilic ground glass cytoplasm, leading to the diagnosis of MRH. Further thorough work-up evaluation revealed reoccurred breast cancer with left supraclavicular and axillary nodal metastasis.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น
