Cutaneous lesions as a clue for diagnosing systemic sarcoidosis

Authors

  • Atchareeya Sujichanthararat Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Thammasat University
  • Padcha Pongcharoen Division of dermatology, Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand

Keywords:

sarcoidosis, granulomatous disorder

Abstract

Sarcoidosis is a granulomatous disorder of unknown cause that usually involves multiple organs in which skin lesion could be one of the manifestations and may be the first clinical sign of the disease. Diagnosing sarcoidosis is quite challenging in Thailand due to our unfamiliarity with it.

We reported a male patient with asymptomatic rash in which skin biopsy revealed naked granuloma with no evidence of infection. After reviewing his previous history of asymptomatic abnormal chest radiograph which was diagnosed smear-negative pulmonary tuberculosis with complete nine-month course of anti-tuberculosis medications. He was performed bronchoscopy with tissue biopsy and revealed non-caseating granuloma with no evidence of infection. All of these had led to the diagnosis of systemic sarcoidosis.

References

Sanchez M, Haimovic A, Prystowsky S. Sarcoidosis. Dermatol Clin 2015; 33: 389-416.

Heinle R, Chang C. Diagnostic criteria for sarcoidosis. Autoimmun Rev 2014; 13: 383-7.

Dacosta JL. Geographic epidemiology of sarcoidosis in southeast asia. Am Rev Respir Dis 1973; 108: 1269-72.

Haimovic A, Sanchez M, Judson MA, Prystowsky S. Sarcoidosis: A comprehensive review and update for the dermatologist. J Am Acad Dermatol 2012; 66: 699.e1-e18.

Tchernev G. Cutaneous sarcoidosis: the “great imitator”: etiopathogenesis, morphology, differential diagnosis, and clinical management. Am J Clin Dermatol 2006; 7: 375-82.

Liu KL, Tsai WC, Lee CH. Cutaneous sarcoidosis A retrospective case series and a hospital-based case-control study in Taiwan. Medicine (Baltimore) 2017; 96: e8158.

García-Colmenero L, Sánchez-Schmidt JM, Barranco C, Pujol RM. The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases. Int J Dermatol 2019; 58: 178-84.

Goyal A, Khilnani G, Das A, Naranje P, Bhalla A, Guleria R. Dilemma of diagnosing thoracic sarcoidosis in tuberculosis-endemic regions: An imaging-based approach. Part 2. Indian J Radiol Imaging 2017; 27: 380-8.

Wu MC, Lee JY. Cutaneous sarcoidosis in southern Taiwan: Clinicopathologic study of a series with high proportions of lesions confined to the face and angiolupoid variant. J Eur Acad Dermatology Venereol 2013; 27: 499-505.

Arias-Santiago S, Fernández-Pugnaire MA, Aneiros-Fernández J, et al. Recurrent Telangiectasias on the Cheek: Angiolupoid Sarcoidosis. Am J Med 2010; 123: e7-e8.

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Published

2019-12-27

How to Cite

Sujichanthararat, A., & Pongcharoen, P. (2019). Cutaneous lesions as a clue for diagnosing systemic sarcoidosis. Thai Journal of Dermatology, 35(4), 206–211. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/195136

Issue

Vol. 35 No. 4 (2019): October - December

Section

Case Report

License

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