Lenalidomide-induced hand-foot syndrome: A case report

Authors

  • Tarinee Sasiprapa Dermatology department, Phramongkutklao hospital
  • Julphat Intarasupht Division of Dermatology, Department of Medicine, Phramongkutklao Hospital, Ratchathewi, Bangkok, Thailand

Keywords:

Hand-foot syndrome, palmoplantar erythrodysesthesia, chemotherapy-induced acral erythema, lenalidomide

Abstract

Hand-foot syndrome (HFS, palmoplantar erythrodysesthesia, chemotherapy-induced acral erythema) is a reaction which occurs after administration of systemic medications especially chemotherapeutic drugs. The usual clinical presentations include erythema, edema and a burning pain on the palms and soles. To the best of our knowledge, hand-foot syndrome caused by lenalidomide has never been reported.

We reported a case of a 57 year-old Thai woman with multiple painful edematous papules on her palms and soles after receiving lenalidomide in the treatment of relapsed and refractory multiple myeloma. The clinical and histopathologic findings are compatible with hand-foot syndrome. She was diagnosed with lenalidomide-induced hand-foot syndrome and treated with topical steroid and dose reduction of lenalidomide. The resolution of disease was observed at a 3-week follow-up visit.

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Published

2019-12-27

How to Cite

Sasiprapa, T., & Intarasupht, J. (2019). Lenalidomide-induced hand-foot syndrome: A case report. Thai Journal of Dermatology, 35(4), 193–197. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/208008