Thyroid fibrosarcoma associated with neurofibromatosis type 1: A case report

Authors

  • Chankiat Songsantiphap DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE, CHULALONGKORN UNIVERSITY, BANGKOK, THAILAND.
  • Chanat Kumtornrut DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE, CHULALONGKORN UNIVERSITY, BANGKOK, THAILAND.

Keywords:

Neurofibromatosis type 1, thyroid fibrosarcoma

Abstract

SONGSANTIPHAP C, KUMTORNRUT C. THYROID FIBROSARCOMA ASSOCIATED WITH NEUROFIBROMATOSIS TYPE 1: A CASE REPORT. THAI J DERMATOL 2020;36:78-82.

DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE, CHULALONGKORN UNIVERSITY, BANGKOK, THAILAND.

Neurofibromatosis (NF) is a neurocutaneous genetic disorder that is associated with various clinical phenotypes expressed by neural crest-derived organs including nervous, cutaneous and skeletal systems1. Among various types, NF type 1 (NF-1) has the most specific skin features and diagnostic criteria. It is inherited as an autosomal dominant fashion with an incidence of 1 in 3,000 live births; however, approximately 50% of cases are due to spontaneous mutation2. Besides, there are well-established associations of benign and malignant tumors with NF-1, most of which are of neural origin such as optic pathway tumors3, and particularly malignant peripheral nerve sheath tumors4. On the contrary, few cases are reporting the co-existence of non-neurogenic sarcomas with NF-15.

In this report, we present a patient with rare non-neurogenic sarcoma, thyroid fibrosarcoma, uncommonly associated with NF-1.

Author Biography

Chanat Kumtornrut, DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE, CHULALONGKORN UNIVERSITY, BANGKOK, THAILAND.

WANTAVORNPRASERT  K,  WITITSUWANNAKUL  J . THE  ERUPTION  OF  MULTIPLE  BULLOSIS DIABETICORUM ALONG WITH HYPERGLYCEMIC STATE AFTER RECEIVING HIGH DOSE SYSTEMIC CORTICOSTEROID. THAI J DERMATOL 2019; 35: 182 - 186 . DIVISION  OF  DERMATOLOGY,  DEPARTMENT  OF INTERNAL  MEDICINE,  FACULTY  OF  MEDICINE, CHULALONGKORN UNIVERSITY, BANGKOK, THAILAND .

References

Bergqvist C, Servy A, Valeyrie-Allanore L, Ferkal S, Combemale P, Wolkenstein P. Neurofibromatosis 1 French national guidelines based on an extensive literature review since 1966. Orphanet J Rare Dis 2020;15:37.

Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ. Neurofibromatosis type 1. Nat Rev Dis Primers 2017;3:17004.

Lobbous M, Bernstock JD, Coffee E, et al. An Update on Neurofibromatosis Type 1-Associated Gliomas. Cancers (Basel) 2020;12:114.

Chung YH, Jang JW, Cho JY. Soft tissue sarcoma in neurofibromatosis type 1: A rare case of malignant peripheral nerve sheath tumor of the skin. Arch Plast Surg 2020;47:92-6.

Ferrari A, Bisogno G, Macaluso A, et al. Soft-tissue sarcomas in children and adolescents with neurofibromatosis type 1. Cancer 2007;109:1406-12.

Denayer E, de Ravel T, Legius E. Clinical and molecular aspects of RAS related disorders. J Med Genet 2008 ;45:695-703.

Folpe AL. Fibrosarcoma: a review and update. Histopathology 2014;64:12-25.

Zouhair N, Chaouki A, Ballage A, et al. Fibrosarcoma of the ethmoid sinus: A rare entity. Int J Surg Case Rep 2019;59:136-9.

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Published

2020-06-16

How to Cite

Songsantiphap, C., & Kumtornrut, C. (2020). Thyroid fibrosarcoma associated with neurofibromatosis type 1: A case report. Thai Journal of Dermatology, 36(2), 78–82. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/240549

Issue

Vol. 36 No. 2 (2020): April - June

Section

Case Report

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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ

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