Cutaneous Rosai-Dorfman Disease: A Case Report of Rare Presentation of Rosai-Dorfman Disease

Authors

  • Jidapa Arpornpattanapong INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND.
  • Walaiorn Pratchyapruit INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND.
  • Poonnawis Sudtikoonaseth INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND.
  • Pimpa Tantanasrigul INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND.

Keywords:

Rosai-dorfman disease, sinus histiocytosis with massive lymphadenopathy, cutaneous rosai-dorfman disease

Abstract

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy, is a rare benign non-Langerhans cell histiocytosis characterized by proliferation of activated histiocytes within the affected tissues. Massive, painless lymphadenopathy is a classic presentation, usually affected male children and young adults. Extranodal involvement is reported in some cases. Isolated cutaneous involvement is very rare. We report a 48-year old Thai male presented with multiple, non-scaly erythematous to yellowish papules and plaques on the face for 17 months without lymphadenopathy. Histopathology showed dense infiltration of histiocytes, lymphocytes and plasma cells in dermis with emperipolesis phenomenon. Immunohistochemistry demonstrated positive S100 protein and weakly positive CD68. The clinical presentation and histopathological results were compatible with cutaneous Rosai-Dorfman disease.

References

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Published

2021-03-17

How to Cite

Arpornpattanapong, J., Pratchyapruit, W., Sudtikoonaseth, P., & Tantanasrigul, P. (2021). Cutaneous Rosai-Dorfman Disease: A Case Report of Rare Presentation of Rosai-Dorfman Disease. Thai Journal of Dermatology, 37(1), 37–43. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/247912

Issue

Vol. 37 No. 1 (2021): January - March

Section

Case Report

License

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