A Possible New Variants of Familial Syringoma: Case Reports and Review of Literature

Abstract

Syringoma is a benign tumor of the intraepidermal portion of eccrine sweat ducts with distinct histopathology features, including the characteristic comma (tadpole)-shaped tail comprised of dilated, cystic eccrine ducts. Syringoma was classified into four main clinical variants: localized, familial, a variant associated with Down syndrome, and a generalized form with multiple and eruptive syringoma.

In familial eruptive syringoma is a rare form of syringoma. The clinical presentations are firm, smooth, skin-colored to pigmented, discrete papules that appear as successive crops on the anterior body surface of individuals who also have one or more family members with similar eruptive or localized lesions. Treatment of these benign conditions is a cosmetic purpose by destructive methods, medical therapies or a new treatment modality such as botulinum toxin A.

This report presents two cases of familial eruptive syringoma at the Institute of Dermatology in Thailand and literature reviews  of  familial  eruptive  syringoma: The first case,  a 15-year-old Thai female presented with eruptive syringoma on the left lower eyelid, neck, antecubital fossae, groins, and mon pubis and her mother also had syringoma on the lower eyelids. In the second case, a 15-year-old Thai female presented with eruptive syringoma on the face, trunk, back, and extremities, as well as her father and uncle.