The Use of Steroids in the Treatment of Severe Hypercalcemia Complication in Newborn with Subcutaneous Fat Necrosis: A Case Report

Authors

  • Nicharee Thamsirisup DEPARTMENT OF PEDIATRICS, FACULTY OF MEDICINE, NARESUAN UNIVERSITY, PHITSANULOK, THAILAND.
  • Klaita Srisingh DEPARTMENT OF PEDIATRICS, FACULTY OF MEDICINE, NARESUAN UNIVERSITY, PHITSANULOK, THAILAND.

Keywords:

Hypercalcemia, subcutaneous fat necrosis, neonate, infant

Abstract

Subcutaneous fat necrosis (SCFN) is usually a benign disorder, which occurs within the six weeks of life in term and post-term infants and is resolved spontaneously. However, some patients may develop a rare complication of hypercalcemia due to SCFN, which requires prompt treatment. The exact pathophysiology of this condition is still unknown. Currently, there is no consensus on the treatment guidelines of hypercalcemia in newborns with SCFN. Other studies have  found  that  intravenous fluid

hydration, calcium-wasting diuretics, dietary calcium restriction and use of corticosteroids and bisphosphonates are all effective treatments. However, details regarding the dosage and duration of steroid treatment have not been thoroughly investigated. This study reports a case of 1-month-old newborn presented with severe hypercalcemia complication secondary to SCFN.

Our goal is to provide a detailed treatment outline of severe hypercalcemia as a complication of SCFN in similar healthcare facilities with limited resources.

References

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Alsofyani AK. Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin. Saudi Med J 2018;39:622-6.

Stefanko NS, Drolet BA. Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature. Pediatr Dermatol 2019;36:24-30.

Samedi VM, Yusuf K, Yee W, Obaid H, Al Awad EH. Neonatal hypercalcemia secondary to subcutaneous fat necrosis successfully treated with pamidronate: a case series and literature review. AJP Rep 2014;4:e93-6.

Shumer DE, Thaker V, Taylor GA, Wassner AJ. Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications. Arch Dis Child Fetal Neonatal Ed 2014;99:F419-21.

Alos N, Eugène D, Fillion M, Powell J, Kokta V, Chabot G. Pamidronate: Treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis. Horm Res 2006;65:289-94.

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Published

2022-06-08

How to Cite

Thamsirisup, N. ., & Srisingh, K. (2022). The Use of Steroids in the Treatment of Severe Hypercalcemia Complication in Newborn with Subcutaneous Fat Necrosis: A Case Report. Thai Journal of Dermatology, 38(2), 75–81. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/257159

Issue

Vol. 38 No. 2 (2022): April - June 2022

Section

Case Report

License

Copyright (c) 2022 Thai Journal of Dermatology

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ

บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น