Acquired Cutaneous Pretibial Mucinosis in an Overweight Patient with Chronic Venous Insufficiency: A Case Report and Literature Review
Keywords:
stasis mucinosis, pretibial myxedema, obesity-associated lymphedematous mucinosis, cutaneous mucinosisAbstract
Localized acquired cutaneous pretibial mucinosis is characterized by abnormal deposition of mucin in the dermis, which can be either a primary or secondary lesion associated with systemic disease, especially hyperthyroidism in Graves’ disease. Stasis mucinosis and obesity-associated lymphedematous mucinosis have been described as new and uncommon conditions. That are different entities of pretibial mucinosis without altered thyroid function. These two conditions are similar and have been described as associated with chronic venous insufficiency, increased body mass index, and chronic lymphedema. We presented a case of chronic erythematous and edematous plaques with vesicles on both shins in an overweight man with chronic venous insufficiency. Differential diagnosis among cellulitis-mimic conditions with associated vesiculobullous eruption was detailed. The final diagnosis was supported by clinicopathological correlation.
References
Fatourechi V. Pretibial myxedema: pathophysiology and treatment options. Am J Clin Dermatol 2005;6:295-309.
Rongioletti F. New and emerging conditions of acquired cutaneous mucinoses in adults. J Eur Acad Dermatol Venereol Published Online First: 5 February 2022. doi: 10.1111/jdv.17983. Epub ahead of print. PMID: 35124832.
Ferreli C, Atzori L, Rongioletti F. Obesity-associated lymphedematous mucinosis and stasis mucinosis. Clin Dermatol 2021;39:229-232.
Somach SC, Helm TN, Lawlor KB, et al. Pretibial mucin. Histologic patterns and clinical correlation. Arch Dermatol 1993;129:1152-6.
Kim KJ, Kim HH, Chang SE, et al. A case of pretibial mucinosis without thyroid disease. J Dermatol 2002;29:383-5.
Tokuda Y, Kawachi S, Murata H, et al. Chronic obesity lymphedematous mucinosis: three cases of pretibial mucinosis in obese patients with pitting oedema. Br J Dermatol 2006;154:157-61.
Rongioletti F, Donati P, Amantea A, et al. Obesity-associated lymphedematous mucinosis. J Cutan Pathol 2009;36:1089-94.
Castiñeiras I, del Pozo J, Robles O, et al. Euthyroid nodular pretibial mucinosis: palliative treatment with carbon dioxide laser. Dermatol Surg 2009;35:719-21.
Pugashetti R, Zedek DC, Seiverling EV, et al. Dermal mucinosis as a sign of venous insufficiency. J Cutan Pathol 2010;37:292-6.
Mir M, Jogi R, Rosen T. Pretibial mucinosis in a patient without Grave’s disease. Cutis 2011;88:300-2.
Brauns B, Mempel M, Schön MP, et al. Multiple slowly growing nodular lesions on the lower legs in a 78-year-old obese woman. Nodular obesity-associated lymphedematous mucinosis. JAMA Dermatol 2013;149:867-8.
Woolf RT, Ferrara G, Rongioletti F, et al. Unusual plaque and papules affecting the legs. Clin Exp Dermatol 2014;39:245-7.
Karadag AS, Ozlu E, Ozkanli S. Obesity-associated lymphedematous mucinosis. Indian J Dermatol Venereol Leprol 2014;80:456-7.
Milman L de M, Grill AB, Müller GP, et al. Pretibial mucinosis in an euthyroid patient. An Bras Dermatol 2016;91:100-2.
Ferreli C, Pinna AL, Pilloni L, et al. Obesity-associated lymphedematous mucinosis: Two further cases and review of the literature. Dermatopathology (Basel) 2018;5:16-20.
Hirt PA, MacQuhae FE, Cho-Vega JH, et al. Stasis mucinosis: Insights into euthyroid localized mucinosis. Wounds 2019; 31: E58-E560.
Keller EC, Tomecki KJ, Alraies MC. Distinguishing cellulitis from its mimics. Cleve Clin J Med 2012;79:547-52.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Thai Journal of Dermatology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น
