Multiple Eruptive Dermatofibromas in a Patient with Systemic Lupus Erythematosus, Lupus Nephritis and Receiving Immunosuppressive Drugs: A Case Report

Authors

  • Kritsada Khiewplueang DEPARTMENT OF DERMATOLOGY, FACULTY OF MEDICINE SIRIRAJ HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND.
  • Kanchalit Thanomkitti DEPARTMENT OF DERMATOLOGY, FACULTY OF MEDICINE SIRIRAJ HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND.

Keywords:

Multiple dermatofibromas, SLE, lupus nephritis, immunosuppression

Abstract

Multiple eruptive dermatofibromas (MEDFs) are a rare condition, found in only less than 0.3% of all dermatofibromas.  The occurrence of more than 5 lesions within the period of 4 months or the presence of more than 15 lesions in any period is the current definition of MEDFs. This variant of the disease has been thought to be related to immune dysregulation. Inhibiting down-regulatory T cells may contribute to the development of MEDFs in immunodeficient states; otherwise, dermatofibromas may arise in response to a potential pathogen that the immune system is unable to eradicate.  In this report, we describe a 32-year-old woman with underlying systemic lupus erythematosus, lupus nephritis, and received oral prednisolone, cyclosporine and azathioprine. She presented with multiple small brownish nodules approximately 12 lesions over a period of 3 months on both lower extremities. 

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Published

2022-12-19

How to Cite

Khiewplueang, K., & Thanomkitti, K. (2022). Multiple Eruptive Dermatofibromas in a Patient with Systemic Lupus Erythematosus, Lupus Nephritis and Receiving Immunosuppressive Drugs: A Case Report. Thai Journal of Dermatology, 38(4), 154–158. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/259464