Subcutaneous Basidiobolomycosis: A Report of Young Thai Lady

Authors

  • Chachrist Tuchinda Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Thailand.
  • Panlop Chakkavittumrong Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Thailand.
  • Suttichai Visuttichaikit Division of Infectious diseases, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Thailand.

Keywords:

Basidiobolomycosis, Subcutaneous Basidiobolomycosis, Painless Mass, Painless Subcutaneous Mass

Abstract

Subcutaneous basidiobolomycosis is a rare chronic granulomatous infection caused by Basidiobolus ranarum. We present the case of a 22-year-old Thai woman who, without a history of trauma, presented with painless masses extending from the left flank to the left thigh over the course of one year. Notably, the condition failed to respond to a six-month course of anti-tuberculosis medication. Subsequent investigations, including skin biopsy, tissue culture, and polymerase chain reaction, conclusively confirmed the diagnosis of subcutaneous basidiobolomycosis. Remarkably, neither clinical assessments nor imaging revealed involvement of other organs except for left posterior gluteus maximus and left lateral tensor fascia latae muscle. The patient achieved complete resolution following a two-month administration of itraconazole at a dosage of 400mg per day.

References

Shaikh N, Hussain KA, Petraitiene R, Schuetz AN, Walsh TJ. Entomophthoramycosis: a neglected tropical mycosis. Clin Microbiol Infect 2016;22:688-94.

Sethy M, Sahu S, Sachan S. Basidiobolomycosis: Case Report and Literature Overview. Indian Dermatol Online J 2021;12:307-11.

Patro P, Das P, Sachdev D, Borkar N, Ganguly S, Hussain N. An instance of excellent response of subcutaneous zygomycosis to itraconazole monotherapy. Med Mycol Case Rep 2019;24:13-7.

Mahamaytakit N, Singalavanija S, Limpongsanurak W. Subcutaneous zygomycosis in children: 2 case reports. J Med Assoc Thai 2014;97:S248-53.

Griffiths CEM, Barker J, Bleiker TO, Chalmers R, Creamer D. Rook's Textbook of Dermatology ninth edition: Wiley; 2016.

Kadhirvelu HK, S M, Ramakrishnan R, Premamalini T. Subcutaneous zygomycosis in an immunocompetent patient caused by Basidiobolus ranarum. BMJ Case Rep 2023;16: e253515.

Kumaravel S, Bharath K, Rajesh NG, Singh R, Kar R. Delay and misdiagnosis of basidiobolomycosis in tropical South India: case series and review of the literature. Paediatr Int Child Health 2016;36:52-7.

Hung TY, Taylor B, Lim A, Baird R, Francis JR, Lynar S. Skin and soft tissue infection caused by Basidiobolus spp. in Australia. IDCases 2020;20:e00731.

Acosta-España JD, Voigt K. An old confusion: Entomophthoromycosis versus mucormycosis and their main differences. Frontiers in Microbiology 2022;13:1035100.

Rermluk N, Laolerd W, Chantharit P, Lertsithichai P, Wiratkapun C, Larbcharoensub N. Mammary subcutaneous basidiobolomycosis in a male. Breast J 2017;23:751-3.

De Beule K, Van Gestel J. Pharmacology of Itraconazole. Drugs 2001;61:27-37.

Chantarakul NT, P. Vareenil, J. Phycomycosis. J Med Assoc Thai 1965;48:740-9.

Thasnakorn PS, V. Chantarakul, N. Bhadrakom, S. Subcutaneous mycosis due to Basidiobolus meristosporus: Report of a case. J Med Assoc Thai 1969;52:372-7.

Riganti M, Charoenlarp P, Punpoowong B, Bunnag D, Harinasuta T. Subcutaneous phycomycosis mimics elephantiasis. Southeast Asian J Trop Med Public Health 1987;18:479-83.

Singalavanija S, Phuvichit B, Limprutithum T, Hemsrichrt V. Subcutaneous Phycomycosis: A Case Report. Bull Dept Med Serv 1987;12:505-8.

Prakitrittranon W. Subcutaneous Zygomycosis (Basidiobolomycosis): Report of A Case. Thai J Dermatol 1992;8:215-20.

Viravan S. Disseminated chronic subcutaneous zygomycosis. Thai Journal of Pediatrics 1997;36:292-6.

Mahaisavariya P, Chaiprasert A, Sivayathorn A, Khemngern S. Deep fungal and higher bacterial skin infections in Thailand: clinical manifestations and treatment regimens. Int J Dermatol 1999;38:279-84.

Chiewchanvit S, Khamwan C, Pruksachatkunakorn C, Thamprasert K, Vanittanakom N, Mahanupab P, et al. Entomophthoromycosis in Maharaj Nakorn Chiang Mai Hospital. J Med Assoc Thai 2002;85:1089-94.

Choonhakarn C, Inthraburan K. Concurrent subcutaneous and visceral basidiobolomycosis in a renal transplant patient. Clin Exp Dermatol 2004;29:369-72.

Kraimak S, Janjumratsang P. Subcutaneous zygomycosis due to Basidiobolus ranarum: a case report. Thai J Dermatol 2012;28:143-9.

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Published

2024-09-06

How to Cite

Tuchinda, C., Chakkavittumrong, P., & Visuttichaikit, S. (2024). Subcutaneous Basidiobolomycosis: A Report of Young Thai Lady. Thai Journal of Dermatology, 40(3), 61–67. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/267248