Childhood-Onset Epidermolysis Bullosa Acquisita Successfully Treated with Colchicine and a Super-potent Topical Corticosteroid: A Case Report

Abstract

Epidermolysis bullosa acquisita (EBA) is an uncommon autoimmune disorder that results in subepidermal blister formation. The clinical manifestations vary depending on subtype. In the classical form, tense bullae or erosions present on non-inflamed skin, accompanied by scars and milia in trauma-prone areas. In the non-classical form, blisters can appear on both non-inflamed and inflamed skin, resembling other autoimmune blistering diseases. The diagnosis relies on histology, immunofluorescence, and serological testing demonstrating autoantibody targeting type-VII collagen which is an element of anchoring fibrils located at sublamina densa of the basement membrane in skin and mucosal tissues. The treatment is challenging since the data on the efficacy of therapeutic options is still scarce. Herein, we reported a rare childhood-onset EBA case successfully treated with colchicine and a super-potent topical corticosteroid.