The effects of tetrahydrocurcumin (THC) in curcuminoid cream on the hydration, elasticity and color of human skin

Abstract

Tetrahydrocurcumin (THC) plays an important role in the antioxidant mechanism resulting in the significant neutralization of free radicals in a dose-dependent manner. Recent studies revealed the superior free radical scavenging ability of THC. This action is of particular interest for cosmetics, in terms of, ultraviolet protection and anti-aging preparations.

Objective: To study the efficacy of THC and liposome in curcuminoid cream (GPO curmin, Government Pharmaceutical Organization) in hydration, elasticity, and color of human skin

Methods: Eighty female volunteers aged 30-45 years with normal skin were recruited to the study. The volunteers were randomly divided into 4 groups and treated with; (A) GPO curmin cream containing both THC and liposome, (B) GPO curmin cream containing THC without liposome, (C) GPO curmin cream containing liposome without THC, and (D) vehicle controlled cream. All volunteers were asked to apply 1 gram of cream on their face twice a day for 4 weeks. Skin hydration, elasticity, and color were measured at baseline and 4 weeks after treatment by Corneometer CM 825, Cutometer MPA 580, and Dermospectrometer, respectively, at chin and both cheeks. 

Results: Seventy eight subjects (20 in group A, 20 in group B, 19 in group C, and 19 in group D) completed treatment protocol. The baseline skin hydration, elasticity, and color in all groups were not significantly different (p=0.954, p=0.727, and p=0.560, respectively). Skin hydration, elasticity, and color at 4 weeks after treatment in all groups also demonstrated no significant differences (p=0.570, p=0.137, and p=0.445, respectively). Skin hydration was significantly decreased in group C (p=0.030). Skin elasticity was significantly increased in group A, C and D (p=0.002, p<0.001, and p=0.021, respectively). Skin color was significantly improved in all groups (p<0.001)

Conclusions: THC and liposome provided no improvement in skin hydration in all groups. Significant lighter in skin color were found in all groups. Skin elasticity was improved in all group, except group B. The other ingredients in vehicle might be responsible for these significant results.