Clinical Studies to Demonstrate the Efficacy of a Liquid Cleanser Containing 0.15% Trichlorocarbanilide (TCC)

Deepali Date; Veerja Gupte; Mithila Bhadsawale; Uma Ayachit; Komal Patel; Susan Mortillo; S P Bhandare; Mark Vandeven; Surang Chatdamrongmongkol

Authors

Deepali Date KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Veerja Gupte KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Mithila Bhadsawale KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Uma Ayachit KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Komal Patel KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Susan Mortillo KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
S P Bhandare KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Mark Vandeven KELKAR EDUCATION TRUST SCIENTIFIC RESEARCH CENTER, MUMBAI, INDIA
Surang Chatdamrongmongkol COLGATE-PALMOLIVE (THAILAND) LTD

Keywords:

Liquid cleanser, antibacterial ingredient, trichlorocarbanilide, TCC

Abstract

Background: Hand washing is an effective procedure to protect against infection risk. Health care associated infections or HCAI are associated with hospital-acquired infection, the prolongation of hospitalization as well as enhanced morbidity and mortality rates. Reducing HCAI by an effective hand washing technique using antibacterial cleansers or soaps is recommended.

Objective: To demonstrate the effectiveness of a liquid cleanser with 0.15% trichlorocarbanilide (TCC) to eliminate transient microbial flora from the hands when used in a handwashing procedure, and to inhibit the growth of transient bacteria compared to an ordinary soap.

Materials and Methods: The clinical studies were designed to demonstrate the efficacy of a liquid cleanser containing 0.15% TCC against marker organisms such as Gram negative (Escherichia coli) or Gram positive (Staphylococcus aureus) bacteria. The handwash method used E. coli as the marker organism and was based on ASTM (American Society for testing and materials) E1174. The cup scrub method used S. aureus as the marker organism and was based on a modification of ASTM E1874.

Results: Twenty subjects completed these 2 studies. After a single hand wash with liquid cleanser containing 0.15% TCC the log₁₀ reduction of E. coli was 3.24 (99.94%). The log₁₀ reduction of S. aureus compared to an ordinary bar soap using the modified cup scrub method was 2.05 for the liquid cleanser containing 0.15% TCC.

Conclusion: A liquid cleanser containing 0.15 % TCC was highly effective against both Gram negative and Gram positive bacteria. The liquid cleanser eliminated 99.94% of E. coli and showed significant residual antibacterial protection against S. aureus bacteria compared to an ordinary bar soap.

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