Efficacy of Fractional Laser Photothermolysis in the Treatment of Atrophic Acne Scar in Thai Patients, Comparison between 25 mJ, 250 MTZS/cm2 and 25 mJ, 500 MTZS/cm2 : A Randomized Single-blind Split Face Study
Keywords:
Fractional laser photothermolysis, Acne scarAbstract
Background: Fractional photothermolysis represents a method of treatment for acne scars without significant side effects.
Objective: To evaluate the effectiveness and side effects of the fractional laser in the treatment of atrophic acne scar and compare the results between different treatment density.
Material and Methods: 46 patients were enrolled in this trial. Each patient was randomized to receive treatment on half of the face with fractional photothermolysis 25 mJ, 250 MTZs/cm2, while the other half was treated with 25 mJ, 500 MTZs/cm2.The treatments were done with 1,550 nm Erbium fiber fractional laser every 4 weeks for 5 sessions. Clinical assessments and side effects graded by dermatologists were also obtained pretreatment and at 4,12 and 24 weeks after the last treatment.
Result: Modest improvement in acne scars was observed in majority of patients on both sides with minimal side effects.
Conclusion: The fractional photothermolysis is an effective treatment for atrophic acne scar.
References
Stathakis V, Kilkenny M, Marks R. Descriptive epidemiology of acne vulgaris in the community. Australas J Dermatol 1997; 38: 115-23.
Tan JK, Vasey K, Fung KY. Beliefs and perceptions of patients with acne. J Am Acad Dermatol 2001; 44: 439-45.
Nanni CA, Alster TS. Complications of carbon dioxide laser resurfacing. An evaluation of 500 patients. Dermatol Surg 1998; 24: 315-320.
Alster TS. Cutaneous resurfacing with CO2 and erbium:YAG lasers: Preoperative, intraoperative and postoperative considerations. Plast Reconstr Surg 1999; 103: 619-632.
Trelles MA. Laser ablative resurfacing for photorejuvenation based on more than a decade’s experience and 1200 patients: Personal observations. J Cosmet Dermatol 2000; 2: 2-13.
Ruiz-Esparza J, Gomez de la Torre OL, Barba Gomez JM: UltraPulse laser skin resurfacing of the hands. Dermatol Surg 1989; 24:69-70
Manstein D, Herron GC, Sink RK, et al. Fractional phothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004; 34: 426-438.
Laubach HJ, Tannous Z, Anderson RR, et al. A histological evaluation of the dermal effects after fractional photothermolysis treatment. Lasers Surg Med 2005; 36(S17):p86.
Hasegawa T, Matsukura T, Mizuno Y, et al. Clinical trial of a laser device called fractional photothermolysis system for acne scars. J Dermatol 2006; 33: 623-7.
Behroozan DS, Goldberg LH, Glaich AS, et al. Fractional photothermolysis for treatment of poikiloderma of civatte. Dermatol Surg 2006; 32: 298-301.
Behroozan DS, Goldberg LH, Dai T, et al. Fractional photothermolysis for the treatment of surgical scars: a case report. J Cosmet Laser Ther 2006; 8 :35-8.
Rokhsar CK, Tse Y, Lee S, et al. A pilot study using fractional photothermolysis in the treatment of scars. Lasers Surg Med 2005; 35(S17):p30.
Rokhsar CK, Tse Y, Lee S, et al. The treatment of photodamage and facial rhytides with Fraxel (fractional photothermolysis). Lasers Surg Med 2005; 36: 32.
Rokhsar CK, Fitzpatrick R. The treatment of melasma with fractional photothermolysis: a pilot study. Dermatol Surg 2005; 31: 1645-50.
Geronemus RG. Fractional photothermolysis: current and future applications. Lasers Surg Med 2006; 38: 169-76.
Dreno B, Khammari A, Orain N, et al. ECCA Grading Scale: An Original Validated Acne Scar Grading Scale for Clinical Practice in Dermatology. Dermatology 2007; 214: 46-51
Fisher GH, Geronemus RG. Short-term side effects of fractional photothermolysis. Dermatol Surg 2005; 31: 1245-9.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น