Safety of Intracameral Levofloxacin Injection on Corneal Endothelial Cell Counts Following Cataract Surgery
Keywords:
Intracameral injection, Levofloxacin, Phacoemulsification, Corneal endothelial cell densityAbstract
Objective: To determine the safety of prophylactic intracameral levofloxacin 0.5% ophthalmic solution on
endothelial cell density in patients having phacoemulsification.
Methods: A prospective blocked randomized control study, 58 eyes were randomized to receive 0.1 ml intracameral
levofloxacin 0.5% (cravit®) or an equal volume of balanced salt solution at the last step of phacoemulsification with
intraocular lens implantation for endophthalmitis prophylaxis. collected parameters, including best-corrected visual
acuity ((BCVA) and intraocular pressure were evaluated preoperatively, 1 month and 3 months postoperatively.
Endothelial cell density (EDC) and central corneal thickness were evaluated preoperative and 3 month postoperative.
Results: Fifty eight eyes were included, however forty-three eyes completed the study. At 3 months, mean EDC
loss was 17.25% in the intracameral levofloxacin group (n=22) and 12.19% in the control group (n=21) p=0.108.
The mean EDC loss was not statistically significant between groups (p>0.05). There were no statistical significant
differences in BCVA, IOP, CCT between groups at 3 months (p>0.05). No drug related adverse effects and no
endophthalmitis were reported.
Conclusion: Intracameral levofloxacin 0.5% ophthalmic solution demonstrated to be less harmful to visual
rehabilitation, central corneal thickness and corneal endothelial cell density. The administration of 0.1 ml
intracameral levofloxacin 0.5% ophthalmic solution may be used as a choice for endophthalmitis prophylaxis . A
large population may be needed for further study.
Financial Disclosure: The authors have no commercial or proprietary interest in any material or method mentioned
in this article.
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The Thai Journal of Ophthalmology (TJO) is a peer-reviewed, scientific journal published biannually for the Royal College of Ophthalmologists of Thailand. The objectives of the journal is to provide up to date scientific knowledge in the field of ophthalmology, provide ophthalmologists with continuing education, promote cooperation, and sharing of opinion among readers.
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