Biometric and Refractive Changes after Trabeculectomy with Mitomycin C

  • Jomkwan Hengsawat Department of Ophthalmology, Phramongkutklao Hospital
  • Wallop Iemsomboon Department of Ophthalmology, Phramongkutklao Hospital
  • Raveewan Choontanom Department of Ophthalmology, Phramongkutklao Hospital
  • Ornwasee Jatuthong Department of Ophthalmology, Phramongkutklao Hospital
Keywords: Biometric, Keratometry, Anterior chamber depth, Axial length, Refraction, Glaucoma


Objective: The study aimed to evaluate the biometric and refractive changes after trabeculectomy with
mitomycin C ( MMC ) among patients with primary glaucoma.

Design: The study employed a prospective, observational design.
Materials and Methods: We recruited 24 patients with primary glaucoma, scheduled for trabeculectomy
with MMC. Best corrected visual acuity (BCVA), intraocular pressure (IOP), auto-refraction, keratometry,
anterior chamber depth (ACD) and axial length (AXL) were evaluated pre- and postoperatively at 2 weeks,
1, 3 and 6 months.

Results: BCVA, auto-refraction, keratometry (K1, K2) , AXL and ACD showed no significant change over
the course of the study, however postoperative mean IOP significantly decreased at 2weeks, 1, 3 and 6
months of the follow-up period when compared with the pre-operative IOP (p value <0.005), .
Conclusion: No significant difference was found regarding biometric and refractive changes after
trabeculectomy with MMC in patients with glaucoma .

Keywords: , , , , , ,


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Kingman S. Glaucoma is second leading cause of blindness globally. Bull World Health Organ 2004;82(11):887-8.

Leske MC, Heij A, Hussein M, et al. Factors for Glaucoma progression and the effect of treatment. The Early Manifest Glaucoma Trial. Arch Ophthalmol 2003;12 (1):48-56.

Watson PG, Grierson I. The place of trabeculectomy in the treatment of glaucoma. Am Acad Ophthalmol 1981;88(3):175-96.

Cashwell LF, Martin CA. Axial length decrease accompanying successful glaucoma filtration surgery. Ophthalmology 1999;106:2307-11.

Kook MS, Kim HB, Lee SU. Short-term effect of mitomycin-C augmented trabeculectomy on axial length and corneal astigmatism. J Cataract Refract Surg 2001;27:518-23.

Nemeth J, Horoczi Z. Changes in the ocular dimensions after trabeculectomy. Intl Ophthalmol 1992; 16:355-7.

Lamoureux EL, Saw SM, JThumboo J, Wee HL, Aung T, Mitchell P, et al. The impact of corrected and uncorrected refractiveerror on visual functioning: The Singapore Malay Eye Study. Invest Ophthalmol Vis Sci 2009;50:2614-20.

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