Seroma formation after modified radical mastectomy with flap fixation technique in breast cancer patients: Nakhonphanom hospital – a single blinded randomized control trial.
Keywords:
Breast cancer, modified radical mastectomy, flap fixation, seroma formationAbstract
Objective: Seroma formation is the common complication after modified radical mastectomy. The purposes of this study were to evaluate seroma formation after modified radical mastectomy with flap fixation technique and to compared seroma formation after modified radical mastectomy between flap fixation technique and conventional surgery in breast cancer patients.
Patients and methods: This study was a single-blinded randomized control trial. 68 breast cancer patients who underwent modified radical mastectomy by single surgeon were enrolled in this study between December 2023 to June 2024. The patients were randomized to the flap fixation group: group A (n=34) and the conventional group: group B (n=34). Group A, flaps were fixed by absorbable suture to the underlying muscle. Group B, the flaps were closed by conventional methods. All patients were followed 95 – 100 days after discharge and the results of seroma formation were compared between two groups. We used t-test to compare amount of seroma formation between group and multivariable Gaussian regression adjusted for difference factors at baseline.
Results: Seroma formation after discharge developed in 26 patients (38.24%), in flap fixation group (19.23%) lower than conventional group (80.77%), significantly. (p<0.001) There was no significant difference in operative time, blood loss or serious complication between two groups. High BMI and number of axillary lymph node harvest were factors affecting prolong seroma formation after discharge, significantly. (p=0.002 and 0.034)
Conclusion: Flap fixation technique in modified radical mastectomy can reduce fluid from drain after surgery and seroma formation after discharge when compare to conventional technique without the difference in operative time, blood loss or serious complication. High BMI and high number of axillary lymph node harvest are factors affecting prolong seroma formation after discharge.
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