Diffuse pulmonary neuroendocrine cell hyperplasia with tumorlets and elevated serum CEA
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Abstract
Diffuse idiopathicpulmonary neuroendocrine cell hyperplasia (DIPNECH) is a generalized proliferation of scattering single cells, small nodules (neuroendocrine bodies) or linear proliferations of neuroendocrine cells of lung. They may be confined to the bronchial and bronchiolar epithelium, include local extraluminal proliferation (tumorlets), or progress to the develop- ment of carcinoid tumor. Sometimes DIPNECH is accompanied by intra- and extraluminal fibrosis of the involved airways.1,2 It is rare and presents typically in the fifth or sixth decades and is more common in woman.
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