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A huge leap of evolution in neuroimaging has occurred since the invention of magnetic resonance imaging (MRI). In the past, brain imaging with computed tomography (CT) could demonstrate only macro changes of the pathologic lesions. The development of MRI allows us to ‘visualize’ the brain not only as an organ but also at the cellular and molecular level. The developments of biomolecular nanotechnology may help diagnose underlying pathology related biomarkers, for example amyloid plaque in Alzheimer’s disease (AD), or specific neurotransmitters to demon- strate brain images without the necessity for cranial vault opening.
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