Autism and Epilepsy: Practical points that clinicians should aware of

Main Article Content

Montri Saengpattrachai, MD


A 15-year-old high functioning autistic boy with normal IQ was found to have episode of eyes rolling upwards followed by rhythmic body shaking and was unresponsive for 2 minutes


Download data is not yet available.

Article Details

How to Cite
Saengpattrachai M. Autism and Epilepsy: Practical points that clinicians should aware of. BKK Med J [Internet]. 2011 Feb. 18 [cited 2023 Dec. 11];1(1):106. Available from:
Continue Medical Education (CME)


1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association 2000;1943(2):217-250
2. Rapin I. The autistic-spectrum disorders. N Engl J Med 2002;347:302-303
3. Kanner L. Autistic disturbances of affective contact. Nervous Child 1943;2:217-250
4. Barbaresi WJ, Katusic SK, Voigt RG. Autism: A review of the state of the science for pediatric primary health care clinicians. Arch Pediatr Adolesc Med 2006; 160:1167-1175
5. Fombonne E: Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord 2003;33:365-382
6. Landa RJ, Holman KC, Garrett-Mayer E. Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Arch Gen Psychiatry 2007;64:853-864
7. Fombonne E, Zakarian R, Bennett A, et al. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 2006;118:139-150
8. Rapin I, Tuchman RF. What is new in autism? Curr Opin Neurol 2008;21:143-149
9. Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nature Genet 2008;9:341-355
10. Zimmerman AW, Connors SL, Matteson KJ, et al. Maternal antibrain antibodies in autism. Brain Behav Immun 2007;21:351-357
11. Garber K. Neuroscience: autism’s cause may reside in abnormalities at the synapse.Science 2007; 317:190-191
12. Crawley JN. Testing hypotheses about autism. Science 2007;318:56-57
13. Casanova MF. Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy. Neuroscientist 2006;12:435-441
14. Tuchman RF, Rapin I. Epilepsy in autism. Lancet Neurol 2002;1:352-358
15. Volkmar FR, Nelson DS. Seizure disorders in autism. J Am Acad Child Adolesc Psychiatry 1990;29:127-129
16. Steffenburg S, Gillberg C, Steffenburg U. Psychiatric disorders in children and adolescents with mental retar- dation and active epilepsy. Arch Neurol 1996;53:904-912
17. Tuchman RF, Rapin I, Shinnar S. Autistic and dysphasic children, II: epilepsy. Pediatrics 1991;88:1219-1225
18. Binnie C, Channon S, Marston D. Behavioural correlates of interictal spikes. In: Smith D, Treiman D, Trimble M, eds. Neurobehavioural correlates of epilepsy. New York:Raven Press, 1991:113-126
19. Scott RC, Neville BG. Developmental perspectives on epilepsy. Curr Opin Neurol 1998;I1:115-118
20. Chez MG, Chang M, Krasne V, et al. Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav 2006;267-271
21. Small JG: EEG and neurophysiological studies of early infantile autism. Biol Psychiatry 1975;10:385-397
22. Kobayashi R, Murata T. Setback phenomenon in autism and long-term prognosis. Acta Psychiatr Scand 1998;98:296-303
23. Ballaban-Gil K, Tuchman R. Epilepsy and epileptiform EEG: Association with autism and languaged disorders. Ment Retard Dev Disabil Res Rev 2000;6:300-308
24. Gillberg C. The treatment of epilepsy in autism. J Autism Dev Disord 1991;21:61-77
25. Glauser TA. Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy. Epilepsy Behav 2004;5:25-32
26. Marescaux C, Hirsch E, Finck S, et al. Landau-Kleffner syndrome: a pharmacologic study of five cases. Epilepsia 1990;31:768-777
27. Prasad AN, Stafstrom CF, Holmes GL. Alternative epilepsy therapies: the ketogenic diet immunoglobulins, and steroids. Epilepsia 1996;37(suppl 1):81-95
28. Lagae LG, Silberstein J, Gillis PL, Casaer PJ. Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome. Pediatr Neurol 1998;18:165-168
29. Mikati MA, Saab R. Successful use of intravenous immunoglobulin as initial monotherapy in Lan- dau-Kleffner syndrome. Epilepsia 2000;41:880-886
30. Tsuru T, Mori M, Mizuguchi M, Momoi MY. Effects of high-dose intravenous corticosteroid therapy in Landau-Kleffner syndrome. Pediatr Neurol 2000;22:145-147
31. Nass R, Petrucha D. Acquired aphasia with convulsive disorder: a pervasive developmental disorder variant. J Child Neurol 1990;5:327-328
32. Plioplys AV. Autism: electroencephalogram abnor- malities and clinical improvement with valproic acid. Arch Pediatr Adolesc Med 1994;148:220-222
33. Childs JA, Blair JL. Valproic acid treatment of epilepsy in autistic twins. J Neurosci Nurs 1997;29:244-248
34. Hollander E, Dolgoff-Kaspar R, Cartwright C, Rawitt R, Novotny S. An open trial of divalproex sodium in autism spectrum disorders. J Clin Psychiatry 2001;62:530-534
35. Neville BG, Harkness WF, Cross JH, et al. Surgical treatment of severe autistic regression in childhood epilepsy. Pediatr Neurol 1997;16:137-140
36. Nass R, Gross A, Wisoff J, Devinsky O. Outcome of multiple subpial transections for autistic epilepti- form regression. Pediatr Neurol 1999;21:464-470
37. Szabo CA, Wyllie E, Dolske M, Stanford LD, Kotagal P, Comair YG. Epilepsy surgery in children with pervasive developmental disorder. Pediatr Neurol 1999;20:349-353
38. Lewine JD, Andrews R, Chez M, et al. Magnetoen- cephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders. Pediatrics 1999;104:405-418