A Prospective Randomized Trial for Reduction of Serum Low Density Lipoprotein (LDL) with Plant Stanol Ester Mixed in Coffee in a Hypercholesterolemic Thai Population.

Main Article Content

Sant Chaiyodsilp, MD
Paul Chaiyodsilp, MD
Thanavee Pureekul, RN
Rungsiya Srisawas, RN
Yuwaret Khunaphakdipong, MA


OBJECTIVE: To determine whether replacing ordinary coffee with coffee mixed with the plant stanol ester decreases the serum low density lipoprotein (LDL) level in moderately hypercholesterolemic Thais.

MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled trial of a common daily coffee was conducted on May 1, 2012 with continued treatment and follow-up through June 1, 2012. A total of 54 Thais whose serum LDL levels ranged from 130 to 239 mg/dL at randomization, were enrolled and randomized into two groups. The participants consumed a cup of plant stanol mixed coffee or a cup of placebo coffee once a day. The percentage of serum LDL reduction was measured at the end of the study.

RESULTS: Thirty-three subjects were randomized into each group. Forty-seven subjects completed the study, 30 in the group receiving coffee with added plant stanols as ester and 17 in the placebo coffee group. Statistical analysis was done by unpaired t-test using PASW (Predictive Analytics SoftWare) Statistics 18 (SPSS Inc., IL, USA). The results showed a signifi cant difference in mean reduction of LDL levels (p < 0.001, 95% CI = 6.92 – 18.57). The means were 12.77% in the fi rst group and 0.03% in the second group (SD = 9.33 and 9.88, respectively).

CONCLUSION: Among this population of hypercholesterolemic Thais, the daily replacement of an ordinary cup of coffee with a plant stanol mixed coffee reduced serum LDL levels by 12.77% demonstrating the effi cacy of the cholesterol-lowering ingredient in the new food matrix.


Download data is not yet available.

Article Details

How to Cite
Chaiyodsilp S, Chaiyodsilp P, Pureekul T, Srisawas R, Khunaphakdipong Y. A Prospective Randomized Trial for Reduction of Serum Low Density Lipoprotein (LDL) with Plant Stanol Ester Mixed in Coffee in a Hypercholesterolemic Thai Population. BKK Med J [Internet]. 2013Feb.20 [cited 2020Jul.16];50:9. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/218040
Original Article


1. Miettinen TA, Puska P, Gylling H, et al. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 1995;333:1308-12.
2. Athyros VG, Kakafika AI, Papageorgiou AA, et al. Effect of a plant stanol ester-containing spread, placebo spread, or Mediterranean diet on estimated cardiovascular risk and lipid, inflammatory and haemostatic factors. Nutr Metab Cardiovasc Dis 2011;21:213-21.
3. Blair SN, Capuzzi DM, Gottlieb SO, et al. Incremental Reduction of Serum Total Cholesterol and Low-Density Lipoprotein Cholesterol With the Addition of Plant Stanol Ester-Containing Spread to Statin Therapy. Am J Cardiol 2000;86:46-52.
4. Mensink RP, de Jong A, Lütjohann D, et al. Plant stanols dose-dependently decrease LDL-cholesterol concentra- tions, but not cholesterol-standardized fat-soluble anti oxidant concentrations, at intakes up to 9 g/d. Am J Clin Nutr 2010;92:24-33.
5. Gylling H, Hallikainen M, Nissinen MJ, et al. The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins. Clin Nutr 2010 ;29:112-8.
6. Mensink RP, Ebbing S, Lindhout M, et al. Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis 2002;160: 205-13.
7. Plat J, Brufau G, Dallinga-Thie GM , et al. A Plant Stanol Yogurt Drink Alone or Combined with a Low-Dose Statin Lowers Serum Triacylglycerol and Non-HDL Cholesterol in Metabolic Syndrome Patients. J Nutr 2009;139:1143-9.