FDG-PET and FDG production at Wattanosoth
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Published:
Feb 20, 2013
Keywords:
FDG-PET, FDG production, cancer, Wattanosoth Hospital
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Abstract
FDG-PET or Positron Emission Tomography with Fluorode- oxyglucose (fluorine-18-2-fluoro-2-deoxy-D-glucose [FDG]) for oncologic imaging both detects and effectively monitors the therapy of many malignancies. FDG-PET improves the detection and staging of cancer, disease management, therapy selection, and the assessment of appropriate therapeutic responses. Besides the use of FDG-PET in oncology, it can also be used in neurology and cardiology. The clinical use of FDG-PET has flourished over the past 15 years. This article is not meant to be exhaustive, but rather to give an overview and to share some information and experience of FDG-PET and FDG production at Wattanosoth Hospital. It will touch briefly on all aspects of FDG-PET and its production, namely an overview of radioisotope production of F-18, FDG synthesis and quality control.
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1.
Ruangma A. FDG-PET and FDG production at Wattanosoth. BKK Med J [Internet]. 2013 Feb. 20 [cited 2024 Dec. 22];5:80. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/218098
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3. Kostakoglu L, Agress H, Goldsmith SJ. Clinical role of FDG PET in evaluation of cancer patients. Radio- Graphics 2003;23:315-40.
4. Gallagher BM, Fowler JS, Gutterson NI, et al. Metabolic trapping as a principle of radiopharmaceutical design: some factors responsible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose. J Nucl Med 1978;19:1154-61.
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27. Hamacher K, Coenen HH, Stocklin G. Efficient stereo- specific synthesis of no-carrier-added 2-[18F]-fluoro-2- deoxy-D-glucose using aminopolyether supported nucleo- philic substitution. J Nucl Med 1986;27:235-8.
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