Transjugular Intrahepatic Portosystemic Shunt (TIPS)

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Komgrit Tanisaro, MD
Chirotchana Suchato, MD
Rergchai Varatorn, MD


Surgery for portal hypertension began in 1877, with Nicolai Vladirmirovich who performed the À rst portacaval anastomosis. There was little clinical success until Blakemore and Whipple between the 1920’s and 1940’s: the mortality rate ranged from 25-40%. Hepatic encephalopathy was a clinical problem. In 1960, Warren and collegues performed a distal splenorenal shunt, which reduced the incidence of hepatic encephalopathy to an acceptable level.1 Other complications after undergoing successful portacaval anastomosis included ammonia toxicity, responsible for the neuropsychiatric changers seen in patients with impending hepatic coma2 and progressive hypersplenism, inducing thrombocytopenia and leucopenia which can become life-threatening after a shunt procedure.3 Transjugular intrahepatic portosystemic shunt (TIPS) is a less invasive, non-surgical procedure basis which minimizes complications in the treatment of portal hypertension.4 The procedure is mostly performed by Interventional Radiologists (IR) and is effective in selected cases of cirrhosis and portal hypertension.


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Tanisaro K, Suchato C, Varatorn R. Transjugular Intrahepatic Portosystemic Shunt (TIPS). BKK Med J [Internet]. 2013 Sep. 20 [cited 2023 Dec. 6];6(1):59. Available from:
Case Report


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2. Bessman SP, Bessman AN. The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma. J Clin Invest 1955;34:622-8.
3. Redetzki JE, Bickers JN, Samuels M, et al. Progressive hypersplenism after portacaval anastomosis. Report of 3 cases. Am J Dig Dis 1967;12:88-97.
4. Russo MW, Sood A, Jacobson IM, et al. Transjugular intrahepatic portosystemic shunt for refractory ascites: an analysis of the literature on efficacy, morbidity, and mortality. Am J Gastroenterol 2003;98:2521-7.