Mesenchymal Stem Cells

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Petcharin Srivatanakul, PhD

Abstract




Stem cells are a special type of cell, which can be found in almost all types of tissue and through the entire life span of multicellular organisms. Their main function is to provide tissue development, homeostasis and to repair tissue damage. Stem cells are characterised as cells that have the capacity to self renew, multipotency/pluriopotency, clonality, and are divided into embry- onic stem cells and adult stem cells.




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1.
Srivatanakul P. Mesenchymal Stem Cells. BKK Med J [Internet]. 2013Sep.20 [cited 2020Sep.24];6(1):71. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/218639
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References

1. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276:71-4.
2. Rodriguez AM, Elabd C, Amri EZ, et al. The human adipose tissue is a source of multipotent stem cells. Biochimie 2005;87:125-8.
3. Yildirim S, Balci D, Akpinar P, et al. Differentiation potentials of two stroma-resident tissue-specific stem cells. Niche 2012;1:1-7.
4. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-7.
5. Suchanek J, Visek B, Soukup T, et al. Stem cells from human exfoliated deciduous teeth- isolation, long term cultivation and phenotypical analysis. Acta Medica (Hradec Kralove) 2010;53:93-9.
6. Hirata TM, Ishkitiev N, Yaegaki K, et al. Expression of multiple stem cell markers in dental pulp cells cultured in serum-free media. J Endod 2010;36:1139-44.
7. Yu J, He H, Tang C, et al. Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging. BMC Cell Biol 2010;11:32.
8. Iohara K, Zheng L, Wake H, et al. A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp. Stem Cells 2008;26: 2408-18.
9. Liu H, Gronthos S, Shi S. Dental pulp stem cells. Methods Enzymol 2006;419:99-113.
10. Bakopoulou A, Leyhausen G, Volk J, et al. Assessment of the impact of two different isolation methods on the osteo/odontogenic differentiation potential of human dental stem cells derived from deciduous teeth. Calcif Tissue Int 2011;88:130-41.
11. Spath L, Rotilio V, Alessandrini M, et al. Explant-derived human dental pulp stem cells enhance differentiation and proliferation potentials. J Cell Mol Med 2010;14:1635-44.
12. De Rosa A, Tirino V, Paino F, et al. Amniotic fluidderived mesenchymal stem cells lead to bone differentiation when cocultured with dental pulp stem cells. Tissue Eng Part A 2011;17:645-53.
13. Mrozik KM, Zilm PS, Bagley CJ, et al. Proteomic characterization of mesenchymal stem cell-like populations derived from ovine periodontal ligament, dental pulp, and bone marrow: analysis of differentially expressed proteins. Stem Cells Dev 2010;19:1485-99.
14. Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 2009;88:792-806.
15. Oktar PA, Yildirim S, Balci D, et al. Continual expression throughout the cell cycle and down regulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker. Stem Cell Rev 2011;7: 413-24.
16. Laino G, d’Aquino R, Graziano A, et al. A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). J Bone Miner Res 2005;20:1394-402.
17. Struys T, Moreels M, Martens W, et al. Ultrastructural and immunocytochemical analysis of multilineage differentiated human dental pulp- and umbilical cord-derived mesenchymal stem cells. Cells Tissues Organs 2011;193:366-78.
18. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999,284:143-7.
19. Dai LJ, Moniri MR, Zeng ZR, et al. Potential implications of mesenchymal stem cells in cancer therapy. Cancer Lett 2011;305:8-20.
20. Le Blanc K, Pittenger M. Mesenchymal stem cells: progress toward promise. Cytotherapy 2005;7:36-45.
21. Fiorina P, Jurewicz M, Augello A, et al. Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J. Immunol 2009;183:993-1004.
22. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood 2007;110:3499-506.
23. Lu LL, Liu YJ, Yang SG, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 2006;91:1017-26.
24. Wang Y, Han ZB, Song YP, et al. Safety of Mesenchymal stem cells for clinical application. Stem Cells Int 2012; 2012: 652034.
25. Reyes M, Lund T, Lenvik T, et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001;98:2615-25.
26. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-9.
27. Le Blanc K, Ringdén O. Immunobiology of Human Mesenchymal Stem Cells and Future Use in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2005;11:321-34.
28. Friedenstein AJ, Petrakova KV, Kurolesova AI, et al. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968;6:230-47.
29. Friedenstein AJ. Precursor cells of mechanocytes. Int Rev Cytol 1976;47:327-59.
30. Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 1987;20:263-72.
31. Owen ME, Friedenstein AJ. Stromal stem cell: marrowderived osteogenic precursors. Ciba Found Symp 1988; 136:42-60.
32. Hare JM, Traverse JH, Henry TD, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009;54:2277-86.
33. Wernicke CM, Grunewald TG, Juenger H, et al. Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases. Int Arch Med 2011;4:27.
34. Baek SJ, Kang SK, Ra JC. In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors. Exp Mol Med 2011;43:596-603.
35. Shi M, Li J, Liao L, et al. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica 2007;92:897-904.
36. Puglisi MA, Saulnier N, Piscaglia AC, et al. Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives. Eur Rev Med Pharmacol Sci 2011;15:355-64.
37. Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant 2011;20:5-14.
38. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006;98:1076-84.
39. Meirelles Lda S, Fontes AM, Covas DT, et al. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 2009;20:419-27.
40. Uccelli A, Benvenuto F, Laroni A, et al. Neuroprotective features of mesenchymal stem cells. Best Pract Res Clin Haematol 2011;24:59-64.
41. Lu Y, Jin X, Chen Y, et al. Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury. Cell Biochem Funct 2010;28:637-43.
42. Murohara T, Shintani S, Kondo K. Autologous adiposederived regenerative cells for therapeutic angiogenesis. Curr Pharm Des 2009;15:2784-90.
43. Ichim TE, Alexandrescu DT, Solano F, et al. Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy. Cell Immunol 2010;260:75-82.
44. Chen PM, Yen ML, Liu KJ, et al. Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. J Biomed Sci 2011;18:49.
45. Aust L, Devlin B, Foster SJ, et al. Yield of human adiposederived adult stem cells from liposuction aspirates. Cytotherapy 2004;6:7-14.
46. Faustini M, Bucco M, Chlapanidas T, et al. Nonexpanded mesenchymal stem cells for regenerative medicine: yield in stromal vascular fraction from adipose tissues. Tissue Eng Part C Methods 2010;16:1515-21.
47. Premaratne GU, Ma LP, Fujita M, et al. Stromal vascular fraction transplantation as an alternative therapy for ischemic heart failure: anti-inflammatory role. J Cardiothorac Surg 2011;6:43.
48. de la Garza-Rodea AS, van der Velde-van Dijke I, Boersma H, et al. Myogenic properties of human mesenchymal stem cells derived from three different sources. Cell transplantation 2012;21:153-73.
49. Vidal MA, Walker NJ, Napoli E, et al. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue. Stem Cells Dev 2012;21:273-83.
50. Chen Y, Wang G, Zeng L. Adipose tissue or bone marrow, store for purchasing mesenchymal stem cells? Circ J 2011;75:2060-1.
51. Mirsaidi A, Kleinhans KN, Rimann M, et al. Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice. J Tissue Eng Regen Med 2012;6:378-90.
52. Chen HT, Lee MT, Chen CH, et al. Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med 2012;16:582-93.
53. Ahmadian Kia N, Bahrami AR, Ebrahimi M, et al. Comparative analysis of chemokine receptor’s expression in mesenchymal stem cells derived from human bone marrow and adipose tissue. J Mol Neurosci 2011;44:178-85.
54. Rodriguez JP, Murphy MP, Hong S, et al. Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety. Int Arch Med 2012;5:5.
55. Suchánek J, Soukup T, Ivancaková R, et al. Human dental pulp stem cells-isolation and long term cultivation. Acta Medica (Hradec Kralove) 2007;50:195-201.
56. Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 2000;97:13625-30.
57. Miura M, Gronthos S, Zhao M, et al. SHED: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100:5807-12.
58. Karahuseyinoglu S, Cinar O, Kilic E, et al. Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells 2007;25:319-31.
59. Burchfield JS, Dimmeler S. Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair 2008;1:4.
60. Psaltis PJ, Paton S, See F, et al. Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations. J Cell Physiol 2010;223:530-40.
61. Laflamme MA, Murry CE. Regenerating the heart. Nat Biotechnol 2005;23:845-56.
62. Toma C, Pittenger MF, Cahill KS, et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002; 105:93-8.
63. Chen SL, Fang WW, Ye F, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004;94:92-5.
64. Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 2005;102:11474-9.
65. Gnecchi M, Zhang Z, Ni A, et al. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008; 103:1204-19.
66. Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 1970;3:393-403.
67. Mets T, Verdonk G. Variations in the stromal cell population of human bone marrow during aging. Mech Ageing Dev 1981;15:41-9.
68. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 1991;78:55-62.
69. Gronthos S, Graves SE, Ohta S, et al. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Blood 1994;84:4164-73.
70. Gronthos S, Zannettino AC, Hay SJ, et al. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci 2003;116:1827-35.
71. Dennis JE, Carbillet JP, Caplan AI, et al. The STRO-1+ marrow cell population is multipotential. Cells Tissues Organs 2002;170:73-82.
72. Shi S, Gronthos S. Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 2003;18:696-704.
73. Stewart K, Monk P, Walsh S, et al. STRO-1, HOP-26 (CD63), CD49a and SB-10 (CD166) as markers of primitive human marrow stromal cells and their more differentiated progeny: A comparative investigation in vitro. Cell Tissue Res 2003;313:281-90.
74. Zannettino AC , Paton S, Kortesidis A, et al. Human mulipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright/ CD34/CD45(-)/glycophorin-A-bone marrow cells. Hae matologica 2007;92:1707-8.
75. Freyman T, Polin G, Osman H, et al. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J 2006;27:1114-22.
76. Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, et al. The global burden of diabetic foot disease. Lancet 2005; 366:1719-24.
77. Martin P. Wound healing: aiming for perfect skin regeneration. Science 1997;276:75-81.
78. Nishino Y, Yamada Y, Ebisawa K, et al. Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and the possibility of novel cell therapy. Cytotherapy 2011;13:598-605.
79. Kern S, Eichler H, Stroeve J, et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294-301.
80. Lin H, Xu R, Zhang Z, et al. Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases. Cell Mol Immunol 2011;8:19-22.
81. Kidd S, Caldwell L, Dietrich M, et al. Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment. Cytotherapy 2010;12:615-25.
82. Van Poll D, Parekkadan B, Borel Rinkes IH, et al. Mesenchymal stem cell therapy for protection and repair of injured vital organs. Cell Mol Bioeng 2008;1:42-50.
83. Harvard Stem Cell Institute. Stem Cell Science: Overviews of Selected Disease Areas Type 1 Diabetes. 2008; April
84. Couri CE, Voltarelli JC. Stem cell therapy for type 1 diabetes mellitus: a review of recent clinical trials. Diabetol Metab Syndr 2009;1:19.
85. Jiang R, Han Z, Zhuo G, et al. Transplantation of placentaderived mesenchymal stem cells in type 2 diabetes: a pilot study. Front Med 2011;5:94-100.
86. Davatchi F, Abdollahi BS, Mohyeddin M, et al. Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 2011;14:211-5.
87. Honmou O, Houkin K, Matsunaga T, et al. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain 2011;134:1790-807.
88. Karussis D, Karageorgiou C, Vaknin-Dembinsky A, et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol 2010; 67:1187-94.
89. Kitada M, Dezawa M. Parkinson’s disease and mesenchymal stem cells: potential for cell-based therapy. Parkinsons Dis 2012;2012:873706.
90. Politis M, Lindvall O. Clinical application of stem cell therapy in Parkinson’s disease. BMC Med 2012;10:1.
91. Janebodin K, Reyes M. Neural Crest-Derived Dental Pulp Stem Cells Function as Ectomesenchyme to Support Salivary Gland Tissue Formation. Dentistry 2012;S13:001. doi:10.4172/2161-1122.S13-001
92. Ma L, Makino Y, Yamaza H, et al. Cryopreserved dental pulp tissues of exfoliated deciduous teeth is a feasible stem cell resource for regenerative medicine. PLoS One 2012;7:e51777.
93. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105:1815-22.
94. Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439-41.
95. Sun L, Akiyama K, Zhang H, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemiclupus erythematosus mice and humans. Stem Cells 2009;27:1421-32.
96. Yamaza T, Kentaro A, Chen C, et al. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 2010;1:5.
97. Leprince JG, Zeitlin B, Tolar M, et al. Interactions between immune system and mesenchymal stem cells in dental pulp and periapical tissues. Imt Endod J 2012; 45:689-701.
98. Morigi M, Imberti B, Zoja C, et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004;15:1794-804.
99. Hopkins C, Li J, Rae F, et al. Stem cell options for kidney disease. J Pathol 2009;217:265-81.
100. Karaöz E, Demircan PC, Sağlam O, et al. Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells. Histochem Cell Biol 2011;136:455-73.
101. Anversa P, Kajstura J, Rota M, et al. Regenerating new heart with stem cells. J Clin Invest 2013;123:62-70.
102. Braunwald E. Cardiovascular science: opportunities for translating research into improved care. J Clin Invest 2013;123:6-10.
103. Estrela C, Alencar AH, Kitten GT, et al. Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration. Braz Dent J 2011;22:91-8