Comparison of Effectiveness of Pupil Dilatation Methods in Patients of Eye Ear Nose Throat Department at BNH Hospital
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Published:
Sep 20, 2014
Keywords:
pupil dilatation, mydriatic drugs
Main Article Content
Abstract
OBJECTIVE:
This descriptive study aims to compare the effectiveness between two methods of pupil dilatation in patients of the Eye Ear Nose Throat (ENT) Department at the BNH Hospital.
MATERIALS AND METHODS:
The specifically selected subjects are 222 ENT out-patients who received mydriatic agents for an eye examination from January 1, 2014 to February 28, 2014. The mydriatic drugs were administered to these patients using two different methods: 1) a mixture of tropicamide 0.75% and phenylephrine 2.5% given every 5 minutes for 4 times and 2) a mixture of tropicamide 0.75% and phenylephrine 2.5% given every 5 minutes for 2 times. A data collection sheet was designed to record personal information, pupil dilatation method and pupil size at 20, 30 and 45 minutes after drug instillation. The pupil size was measured using a Glasgow Coma Scale instrument. The measurement was done by trained nurses who knew the purpose of this study. The descriptive statistics, which included the number, percentage, mean and standard deviation, were used to present personal information and pupil size at 20, 30 and 45 minutes after drop instillation. The pupil sizes from the two methods were compared by using the non-parametric statistics: Friedman Test and Wilcoxon Signed Rank Test.
RESULTS:
From the comparison at 20, 30 and 45 minutes after the first drop instillation, both methods showed that the difference of pupil size between the time points was statistically significant (p > 0.001). The comparison between the first and the second method illustrates that the difference of pupil size at each time point was not statistically significant (p = 0.032, 0.800 and 0.102, respec¬tively) at the 99.9% confidence interval level. Thus, the second method should be used because it requires only two times of instillation (2 times less than the first method) and the pupil measurement at 20 minutes after the first drop instillation reduces waiting times for patients.
CONCLUSION:
The study supports pupil dilatation by using a mixture of 0.75% Tropicamide plus 2.5% phenylephrine and improves the process by reducing the waiting times of patients. Patients receive a lower amount of the drug, decreasing from 4 times to 2 times, so the risk of side effects is reduced.
This descriptive study aims to compare the effectiveness between two methods of pupil dilatation in patients of the Eye Ear Nose Throat (ENT) Department at the BNH Hospital.
MATERIALS AND METHODS:
The specifically selected subjects are 222 ENT out-patients who received mydriatic agents for an eye examination from January 1, 2014 to February 28, 2014. The mydriatic drugs were administered to these patients using two different methods: 1) a mixture of tropicamide 0.75% and phenylephrine 2.5% given every 5 minutes for 4 times and 2) a mixture of tropicamide 0.75% and phenylephrine 2.5% given every 5 minutes for 2 times. A data collection sheet was designed to record personal information, pupil dilatation method and pupil size at 20, 30 and 45 minutes after drug instillation. The pupil size was measured using a Glasgow Coma Scale instrument. The measurement was done by trained nurses who knew the purpose of this study. The descriptive statistics, which included the number, percentage, mean and standard deviation, were used to present personal information and pupil size at 20, 30 and 45 minutes after drop instillation. The pupil sizes from the two methods were compared by using the non-parametric statistics: Friedman Test and Wilcoxon Signed Rank Test.
RESULTS:
From the comparison at 20, 30 and 45 minutes after the first drop instillation, both methods showed that the difference of pupil size between the time points was statistically significant (p > 0.001). The comparison between the first and the second method illustrates that the difference of pupil size at each time point was not statistically significant (p = 0.032, 0.800 and 0.102, respec¬tively) at the 99.9% confidence interval level. Thus, the second method should be used because it requires only two times of instillation (2 times less than the first method) and the pupil measurement at 20 minutes after the first drop instillation reduces waiting times for patients.
CONCLUSION:
The study supports pupil dilatation by using a mixture of 0.75% Tropicamide plus 2.5% phenylephrine and improves the process by reducing the waiting times of patients. Patients receive a lower amount of the drug, decreasing from 4 times to 2 times, so the risk of side effects is reduced.
Article Details
How to Cite
1.
Kodnguan P, Saelim P. Comparison of Effectiveness of Pupil Dilatation Methods in Patients of Eye Ear Nose Throat Department at BNH Hospital. BKK Med J [Internet]. 2014 Sep. 20 [cited 2024 Nov. 22];8(1):29. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/219724
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Original Article
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References
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3. Anderson HA, Bertrand KC, Manny RE, et al. Comparison of two drug combinations for dilating dark irides. Optom Vis Sci 2010;87:120-4.
4. Majid O, Tabassum R, Keng M.et al. Effective Pupil Dilatation With A Mixture Of 0.75% Tropicamide And 2.5% Phenylephrine: A Randomized Controlled Trial. (Accessed Mar 15, 2014 at http://ispub.com/IJOVS/8/1/11387).
5. Silagy C, Haines A. Evidence-based Practice in Primary Care (2nd ed). 2001 London, England: Selwood Printing.
6. Forman AR. A new low-concentration preparation for mydriasis and cycloplegia. Ophthalmology 1980;87:213-5.
7. Phamonvaechavan P, Chutasmit K, Damrongrak P, et al. Comparison of the effectiveness of mydriasis by two instillation methods of combined 0.75% tropicamide and 2.5% phenylephrine eye drop in preterm infants. J Med Assoc Thai 2012;95:S1-7.
2. Eyeson-Annan ML, Hirst LW, Battistutta D, et al. Comparative pupil dilation using phenylephrine alone or in combination with tropicamide. Ophthalmology 1998;105:726-32.
3. Anderson HA, Bertrand KC, Manny RE, et al. Comparison of two drug combinations for dilating dark irides. Optom Vis Sci 2010;87:120-4.
4. Majid O, Tabassum R, Keng M.et al. Effective Pupil Dilatation With A Mixture Of 0.75% Tropicamide And 2.5% Phenylephrine: A Randomized Controlled Trial. (Accessed Mar 15, 2014 at http://ispub.com/IJOVS/8/1/11387).
5. Silagy C, Haines A. Evidence-based Practice in Primary Care (2nd ed). 2001 London, England: Selwood Printing.
6. Forman AR. A new low-concentration preparation for mydriasis and cycloplegia. Ophthalmology 1980;87:213-5.
7. Phamonvaechavan P, Chutasmit K, Damrongrak P, et al. Comparison of the effectiveness of mydriasis by two instillation methods of combined 0.75% tropicamide and 2.5% phenylephrine eye drop in preterm infants. J Med Assoc Thai 2012;95:S1-7.