Therapeutic Applications of Dental Pulp Stem Cells in Veterinary Medicine: A Case Report
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Abstract
The application of stem cells treatment has been a considerable research focus over the last decade. Several stem cell types have been studied as the potential candidates to restore the structure and function of damaged tissues and organs. The dental pulp stem cells (DPSCs) have shown potential for their use as a novel alternative resource in dentistry and regenerative medicine. DPSCs have mesenchymal stem cell-like (MSC) qualities, including the capacity for self-renewal and multilineage differentiation potential. In this study, we demonstrate the potential applications of DPSCs as a tool to repair damaged tissues and organs. Diseases related to chronic inflammation such as ischemic heart diseases, osteoarthritis, tendonitis, ocular injury and chronic wounds have been investigated through experimental and clinical trial design to clarify the use of DPSCs therapies. Transplantation of DPSCs provided a good choice in terms of tissue regeneration and healing. Our findings suggested that DPSCs might provide a new perspective for translational medicine. However, important points in DPSCs biology, such as homing and immune-regulation require further study of underlying mechanisms to support the application of DPSCs in the future.
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References
2. Fathke C, Wilson L, Hutter J, et al. Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair. Stem Cells 2004;22:812-22.
3. Kim DH, Yoo KH, Choi KS, et al. Gene expression profile of cytokine and growth factor during differentia- tion of bone marrow-derived mesenchymal stem cell. Cytokine 2005;31:119-26.
4. Parikka V, Väänänen A, Risteli J, et al. Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases. Matrix Biol 2005; 24:438-47.
5. Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. PNAS 2000;97:13625-30.
6. Luisa A. DiPietro. Oral Stem Cells: The Fountain of Youth for Epithelialization and Wound Therapy? Adv Wound Care 2012;3:465-7.
7. Riccardo A, Gianpaolo P, Gregorio L, et al. Dental Pulp Stem Cells: A Promising Tool for Bone Regeneration, Stem Cell Rev 2008;4:21-6.
8. Irena P, Olivera S, Natalie CY, et al. Epithelialization in Wound Healing: A Comprehensive Review. Adv Wound Care 2013;3:445-64.
9. Jose MV, Manuel M, Angelo S, et al. Controlled, blinded force platform analysis of the effect of intra-articular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs. BMC Vet Res 2013;9:1-6.
10. Konig L, Klopfleisch R, Kershaw O, et al. Prevalence of Biofilms on Surgical Suture Segments in Wounds of Dogs, Cats, and Horses. Vet Pathol 2014. pii: 0300985814535609.
11. Westgate SJ, Percival SI, Knottenbelt DC, et al. Chronic Equine Wounds: What Is the Role of Infection and Biofilms? Wounds.2010;22:138-45.
12. Sood R, Roggy D, Zieger M, et al. Cultured epithelial autografts for coverage of large burn wounds in eighty- eight patients: the Indiana Univer-sity experience. J Burn Care Res 2010;31:559-68.
13. Whang KK, Kim MJ, Song WK, et al. Comparative treatment of giant congenital melanocytic nevi with curettage or Er: YAG laser ablation alone versus with cultured epithelial autografts. Dermatol Surg 2005;31: 1660-7.
14. Petchdee S, Pattanapon N, Bootcha R, et al. Dental Tissue-Derived Stem Cells exerts therapeutic effects on chronic myocardial infarction model of rabbit. The cardiology 2014;9:1-6.
15. Pattanapol N, Tyananupat A, Sriwattanakul P, et al. Reconstruction of damaged cornea epithelium using dental tissue derived stem cells. Cytotherapy 2014;16:S86.
16. Bootcha R, Temvijitr J, Srivatanakul P, et al, Multiple intra-articular transplantations enhances the benefit of dental tissue derived stem cells therapy for the treatment of chronic osteoarthritis. Cytotherapy 2014; 16:S85.
17. Bootcha R, Temvijitr J, Petchdee S. Intra-articular injections with dental pulp stem cells for chronic osteo- arthritis. TJVM 2015;45(1).