Challenges in Production of Alzheimer’s Tracer C-11 PiB
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Published:
Oct 14, 2019
Keywords:
C-11 PiB, Pittsburgh Compound, Alzheimer’s, PET in neurology, beta amyloid tracer
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Abstract
Beta-amyloid plaques and neurofibrillary tangles have been known as the neuro- pathological hallmarks of Alzheimer’s disease. 11C Pittsburgh Compound B (PiB) ([C-11]PiB) is the first successful and well-studied radiopharmaceutical for Positron Emission Tomography (PET) imaging of beta-amyloid deposition in the brain. Although [C-11]PiB has been used in western countries since 2002, Wattanosoth Hospital was the only center with the capacity to produce [C-11]PiB in South-East Asia in 2012. This article describes briefly the challenges the PET radiopharmaceutical team at Wattanosoth Hospital have been facing in the production of [C-11]PiB. It also provides a brief protocol used here for production of [C-11]PiB.
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1.
Ruangma A, Panpitpat S, Saonam T, Kijprayoon S, Ngokpol S, Tanasirimanon M, Khajitkhajonwong S, Tuamputsa S, Rachadara S, Chinvarun Y. Challenges in Production of Alzheimer’s Tracer C-11 PiB. BKK Med J [Internet]. 2019 Oct. 14 [cited 2024 Dec. 23];9(1):70. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/221103
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3. Jack CR, Albert MS, Knopman DS, et al. Inroduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:257-62.
4. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging- Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:263-9.
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7. Price JC, Klunk WE, Lopresti BJ, et al. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 2005;25:1528-47.
8. Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease. Brain 2008;131:1630-45.
9. Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh com- pound-B. Ann Neurol 2004;55:306-19.
10. Rowe CC, Villemagne VL. Brain Amyloid Imaging.J Nucl Med 2011;52:1733-40.
11. Rowe CC, NG S, Ackermann U, et al., Imaging b-amyloid burden in aging and dementia. Neurology 2007;68;1718-25.
12. Edison P, Archer HA, Hinz R, et al. Amyloid hypome- tabolism and cognition in Alzheimer disease: an [11C] PIB and [18F]FDG PET study. Neurology 2007;68:501-98.
13. Kemppainen NM, Aalto S, Wilson IA, et al. Voxel-based analysis of PET amyloid ligan [11C]PIB uptake in Alzheimer disease. Neurology 2006;67:1575-80.
14. Nordberg A. PET imaging of amyloid in Alzheimer’s disease. Lancet Neurol 2004; 3: 519-27.
15. Devanand DP, Mikhno A, Pelton GH, et al. Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patient with Alzheimer disease, mild cognitive impairment, and healthy controls. J Geriatr Psychiatry Neurol 2010;23: 185-98.
16. Klunk WE, Wang Y, Huang GF, et al. The binding of 2-(4’-methylaminophenyl) benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci 2003;23:2086-92.
17. Mathis CA, Bacskai BJ, Kajdasz ST, et al. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett 2002;12:295-8.
18. International Atomic Energy Agency. Cyclotron produced radionuclides: physical characteristics and production methods. Technical Reports Series No. 468. 2009 (Accessed July 25, 2014 at http://www-pub.iaea.org/ MTCD/publications/PDF/trs468_web.pdf).