MRI Findings in Transient Global Amnesia

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Chakorn Chansakul, MD


Transient global amnesia (TGA) is characterized by an attack of temporary anterogradeamnesia without other focal neurological defi cits. Characteristic magnetic resonance imaging (MRI) fi ndings include small, punctate, unilateral or bilateral diffusion restriction in the lateral aspect of the hippocampus, which mostly occurs within 48 hours after symptoms onset. The outcome of TGA is usually excellent. The pathophysiology of TGA remains uncertain, but recent evidence suggests that this disorder may result from the inability to generate new memory in the hippocampus due to vulnerability of CA-1 neurons to metabolic stress.


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Chansakul C. MRI Findings in Transient Global Amnesia. BKK Med J [Internet]. 2016Feb.19 [cited 2020Jul.15];11(1):28. Available from:
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1. Hauge T. Catheter vertebral angiography. Acta Radiol Suppl 1954;109:1-219.
2. Hodges JR, Warlow CP. Syndromes of transient amnesia: towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry 1990;53:834-43.
3. Agosti C, Akkawi NM, Borroni B, et al. Recurrency in transient global amnesia: a retrospective study. Eur J Neurol 2006;13:986-9.
4. Tong DC, Grossman M. What causes transient global amnesia? New insights from DWI. Neurology 2004 22;62:2154-5.
5. Baracchini C, Tonello S, Farina F, et al. Jugular veins in transient global amnesia: innocent bystanders. Stroke 2012;43:2289-92.
6. Uttner I, Prexl S, Freund W, et al. Long-term outcome in transient global amnesia patients with and without focal hyperintensities in the CA1 region of the hippocampus. Eur Neurol 2012;67:155-60.
7. Crowell GF, Stump DA, Biller J, et al. The transient global amnesia-migraine connection. Arch Neurol 1984;41:75-9.
8. Gass A, Gaa J, Hirsch J, et al. Lack of evidence of acute ischemic tissue change in transient global amnesia on single-shot echo-planar diffusion-weighted MRI. Stroke 1999;30:2070-2.
9. Sedlaczek O, Hirsch JG, Grips E, et al. Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology 2004;62:2165-70.
10. Bartsch T, Alfke K, Stingele R, et al. Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae. Brain 2006; 129:2874-84.
11. Weon YC, Kim JH, Lee JS, et al. Optimal diffusion- weighted imaging protocol for lesion detection in transient global amnesia. Am J Neuroradiol 2008;29:1324-8.
12. Ueno H1, Naka H, Ohshita T, et al. Serial changes in delayed focal hippocampal lesions in patients with tran- sient global amnesia. Hiroshima J Med Sci 2010;59:77-81.
13. Inzitari D, Pantoni L, Lamassa M, et al. Emotional arousal and phobia in transient global amnesia. Arch Neurol 1997;54:866-73.
14. Quinette P, Guillery-Girard B, Dayan J, et al. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain 2006; 129:1640-58.
15. Griebe M, Nees F, Gerber B, et al. Stronger pharmacological cortisol suppression and anticipatory cortisol stress response in transient global amnesia. Front Behav Neurosci 2015;9:63.
16. Bartsch T, Deuschl G. Transientglobalamnesia: functional anatomy and clinical implications. Lancet Neurol 2010; 9:205-14.