Adult Onset Immunodeficiency Associated with Anti-interferon Gamma Autoantibodies

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Wannada Laisuan, MD
Chamard Wongsa, MD
Porntip Intapiboon, MD
Nizchapa Dechapaphapeaktak, RN, MS
Malinee Tongdee, RN,BNS
Supa Oncham, SC
Thanuchporn Kafaksom, MS
Ticha Rerkpattanapipat, MD


Adult onset immunodeficiency associated with anti-interferon-gamma autoantibodiesis an emerging medical issue worldwide especially in South-east Asia. Most patientspresent with disseminated non-tuberculous mycobacteria (NTM) infection and otheropportunistic infections. In addition to standard antimicrobial therapy, immunomodulatoror immunosuppressive drug seem to play a role in some cases.
In the present study, we thoroughly reviewed the pathogenesis, clinical features,laboratory diagnosis, modalities of treatment, and clinical outcomes of this condition.


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Laisuan W, Wongsa C, Intapiboon P, Dechapaphapeaktak N, Tongdee M, Oncham S, Kafaksom T, Rerkpattanapipat T. Adult Onset Immunodeficiency Associated with Anti-interferon Gamma Autoantibodies. BKK Med J [Internet]. 2017 Feb. 20 [cited 2023 Dec. 2];13(1):87. Available from:
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