Burn Wound Healing: Pathophysiology and Current Managementof Burn Injury

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Sitthiphon Bunman, MSc
Narongpon Dumavibhat, MD, PhD
Wichai Chatthanawaree, MD
Somboon Intalapaporn, MD
Theerapoan Thuwachaosuan
Chatbodin Thongchuan


Burns are one of the most common causes of injuries. Thermal burns from wetsources (scalds) and dry source (fire or flame) account for 80% of all reported burns.Advances in resuscitation and good management have significantly improved survivalrates after thermal injury. Healthcare providers should understand the pathophysiologyof a burn injury and the current best practice management of wound care. This articlereviews and presents an update to the current management of burn injuries and recentadvances in burn wound care.


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Bunman S, Dumavibhat N, Chatthanawaree W, Intalapaporn S, Thuwachaosuan T, Thongchuan C. Burn Wound Healing: Pathophysiology and Current Managementof Burn Injury. BKK Med J [Internet]. 2017 Sep. 20 [cited 2023 Dec. 10];13(2):91. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/222084
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1. Bunman S, Dumavibhat N, Larbcharoensub N. Evaluation of liver and kidney toxicity in rats receiving proteoglycans from fish cartilage for the acceleration of burn wound healing. BKK Med J 2016;11:11-6.
2. Bunman S, Aramwit P, Larbcharoensub N, et al. Application of proteoglycans from fish cartilage for the acceleration of burn wound healing. TJPS 2015;39 (3): 64-9.
3. Somboonwong J, Kankaisre M, Tantisira B, et al. Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study. J Inter Socie Complementary Medicine Research 2012;12:103.
4. Singer AJ, Dagum AB. Current management of acute cutaneous wounds. N Engl J Med 2008;359:1037-46.
5. Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol 2007;25:9-18.
6. Enoch S, Leaper DJ. Basic science of wound healing. Surgery (Oxford) 2005;26:31-7.
7. Mayers I, Johnson D. The nonspecific inflammatory response to injury. Can J Anaesth1998;45:871-9.
8. LaVan FB, Hunt TK. Oxygen and wound healing. Clin Plast Surg 1990;17:463-72.
9. Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Investig Dermatol Symp Proc 2000;5:40-6.
10. Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol Med (Berl) 1995;73:333-46.
11. Yataes RA, Nanney LB, Gates RE, et al. Epidermal growth factor and related growth factors. Int J Dematol 1991;30:687– 94.
12. Hettiaratchy S, Dziewulski P. ABC of burns. Introduction. BMJ 2004;328:1366-8.
13. Hettiaratchy S, Papini R. Initial management of a major burn: II- assessment and resuscitation. BMJ 2004;329:101-3.
14. Hettiaratchy S, Dziewulski P. ABC of burns: pathophysiology and types of burns. BMJ 2004;328:1,427-9.
15. Cameron AM RNCA. Burn Wound Management: a surgical perspective. Wound Practice & Researc 2010; 18:35-40.
16. Papini R. Management of burn injuries of various depths. BMJ 2004;329:158-60.
17. Murkhtar O, Jone K. trauma injury: burns. BMJ 2003;11: 230-3.
18. Jull AB, Rodgers A, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008:CD005083.
19. Malik KI, Malik MA, Aslam A. Honey compared with silver sulphadiazine in the treatment of superficial partial-thickness burns. Int Wound J 2010;7:413-7.
20. Lockhart SP, Rushworth A, Azmy AA, et al. Topical silver sulphadiazine: side effects and urinary excretion. Burns Incl Therm Inj 1983;10:9-12.
21. Atiyeh BS, Costagliola M, Hayek SN, et al. Effect of silver on burn wound infection control and healing: review of the literature. Burns 2007;33:139-48.
22. Baldi C, Minoia C, Di Nucci A, et al. Effects of silver in isolated rat hepatocytes. Toxicol Lett 1988;41:261-8.
23. Atiyeh BS, Hayek SN, Gunn SW. New technologies for burn wound closure and healing-review of the literature. Burns 2005;31:944-56.
24. Sterling JP, Heimbach DM,Gibran NS. Mangement of the burn wound. ACS Surgery: Principles and Practice. 2010:1-10.
25. Glat PMaLMT. Wound healing. Plastic Surgery, 5th Edition, Grabb and Smith’s. Chapter. 1997:3-25.