The Evaluation of Potential Skin Sensitization and Collagen Synthesis of Rats Receiving Proteoglycan Serum

Main Article Content

Wannara Chuenwattana, Ed.D
Wichai Chatthanawaree, MD
Sitthiphon Bunman, MSc
Hiroshi Yoshikawa, MD


OBJECTIVE: The aim of this study was to evaluate potential skin sensitization andcollagen synthesis of rats receiving proteoglycan (PG) serum.

MATERIAL AND METHODS: Eighteen rats were randomly divided into 3 groupsequally and assigned to receive 1 ml of serum base (control), 1% PG and 2% PG appliedto skin. Histological analysis was evaluated for potential skin sensitization and collagensynthesis on days 7, 14, 21and 28.

RESULTS: Histological analysis showed that 1% PG and 2% PG acceleratedcollagen synthesis. The evaluation of potential skin sensitization, on day 7, 14, 21 and28 of rat applied with 1% PG and 2% PG were not significantly different whencompared to the control group.

Keywords: proteoglycans, collagen synthesis, potential skin sensitization, Trichopoduspectoralis

CONCLUSION: This study demonstrated that PG serum accelerated collagensynthesis and low potential skin sensitization.

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How to Cite
Chuenwattana W, Chatthanawaree W, Bunman S, Yoshikawa H. The Evaluation of Potential Skin Sensitization and Collagen Synthesis of Rats Receiving Proteoglycan Serum. BKK Med J [Internet]. 2018 Feb. 20 [cited 2024 Apr. 23];14(1):1. Available from:
Original Article


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