The Evaluation of Potential Skin Sensitization and Collagen Synthesis of Rats Receiving Proteoglycan Serum

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Published: Feb 20, 2018
DOI: https://doi.org/10.31524/bkkmedj.2018.02.001
Keywords:
proteoglycans, collagen synthesis, potential skin sensitization, Trichopoduspectoralis

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Wannara Chuenwattana, Ed.D
Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University, Bangkok, Thailand
Wichai Chatthanawaree, MD
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Sitthiphon Bunman, MSc
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand , Department of Community and Family Medicine, Faculty of Medicine, Thammasat University.
Hiroshi Yoshikawa, MD
Kochi Red Cross Hospital, Kochi, Japan

Abstract

OBJECTIVE: The aim of this study was to evaluate potential skin sensitization andcollagen synthesis of rats receiving proteoglycan (PG) serum.

MATERIAL AND METHODS: Eighteen rats were randomly divided into 3 groupsequally and assigned to receive 1 ml of serum base (control), 1% PG and 2% PG appliedto skin. Histological analysis was evaluated for potential skin sensitization and collagensynthesis on days 7, 14, 21and 28.

RESULTS: Histological analysis showed that 1% PG and 2% PG acceleratedcollagen synthesis. The evaluation of potential skin sensitization, on day 7, 14, 21 and28 of rat applied with 1% PG and 2% PG were not significantly different whencompared to the control group.

Keywords: proteoglycans, collagen synthesis, potential skin sensitization, Trichopoduspectoralis

CONCLUSION: This study demonstrated that PG serum accelerated collagensynthesis and low potential skin sensitization.

Article Details

How to Cite
1.
Chuenwattana W, Chatthanawaree W, Bunman S, Yoshikawa H. The Evaluation of Potential Skin Sensitization and Collagen Synthesis of Rats Receiving Proteoglycan Serum. BKK Med J [internet]. 2018 Feb. 20 [cited 2026 Oct. 22];14(1):1. available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/222184
Issue
Vol. 14 No. 1 (2018): February
Section
Original Article
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