Oral Malignant Melanoma of the Maxilla: A Case Report

Main Article Content

Pornpop Rattana-arpha, DDS, FRCD
Poramaporn Klanrit, DDS, MS, PhD
Udom Cheusirithavorn, DDS, FRCDT


A case report of oral malignant melanoma (OMM). An 84-year-old male patient presented with enlarged, swollen anterior left upper gingiva with mild pain lasting eight weeks from the lower occluded teeth. Histopathological examination and immunohistochemical studies confirm OMM.
OMM, a neoplasm of melanocytes, is a rare aggressive tumor of the oral cavity. This paper aims to explain and discuss the clinical features, histopathology and immunohistochemical studies of OMM.
We report on a case of OMM treated at our institute. An oral examination, differential diagnosis and biopsy were performed for a definitive diagnosis. RESULTS: Histopathological examination showed sheets of atypical melanocytic tumor cells with abundant cytoplasmic pigmentation. The tumor cells were positive for S-100 protein, HMB-45 and MART 1 or Melan A. A final diagnosis of OMM was made.
OMM is a rare tumor of the oral cavity with a poor prognosis; although an aggressive treatment is available to patients. Early diagnosis and aggressive multimodal treatment are important ways for surgeons to achieve a better outcome for patients with OMM.


Download data is not yet available.

Article Details

How to Cite
Rattana-arpha P, Klanrit P, Cheusirithavorn U. Oral Malignant Melanoma of the Maxilla: A Case Report. BKK Med J [Internet]. 2015 Feb. 20 [cited 2023 Nov. 30];9(1):45. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/238248
Case Report


1. Van der Waal RI, Snow GB, Karim AB, et al. Primary malignant melanoma of the oral cavity: a review of eight cases.Br Dent J 1994;176:185-8.
2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, CA Cancer J Clin 2009;59:225-49.
3. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemio- logy and pathobiology. Oral Oncol 2000;36:152-69.
4. Gu GM, Epstein JB, Morton TH Jr. Intraoral melanoma: longterm follow-up and implication for dental clinicians. A case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;96:404-13.
5. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous mela- noma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998; 83:1664-78.
6. Martınez EA, Alonso FC, Siles MS, et al. Melanoma of the oral mucosa with cerebral metastasis: a clinical case. Oral Oncology EXTRA 2005;41:30-3.
7. Meleti M, Leemans CR, Mooi WJ, et al. Oral malignant melanoma: a review of the literature. Oral Oncol 2007; 43:116-21.
8. Rapini RP, Golitz LE, Greer RO, et al. Primary malignant melanoma of the oral cavity. A review of 177 cases. Cancer 1985;55:1543-51.
9. Prasad ML, Jungbluth AA, Patel SG, et al. Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck. Head Neck 2004;26:1053-7.
10. Tacastacas JD, Bray J, Cohen YK, et al. Update on primary mucosal melanoma. J Am Acad Dermatol 2014;71:366-75.
11. Korabiowska M, Brinck U, Hoenig JF, et al. Significance of P-53 antigen in malignant melanomas and naevi of the head and neck area. Anticancer Res 1995;15:885-9.
12. Chaudhry AP, Hampel A, Gorlin RJ. Primary malignant melanoma of the oral cavity: a review of 105 cases. Cancer 1958;11:923-8.
13. Barker BF, Carpenter WM, Daniels TE, et al. Oral mucosal melanomas: the WESTOP Banff workshop proceedings. Western Society of Teachers of Oral Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:672-9.
14. Tanaka N, Mimura M, Kimijima Y, et al. Clinical inves- tigation of amelanotic malignant melanoma in the oral region. J Oral Maxillofac Surg 2004;62:933-7. Oral Malignant Melanoma of the Maxilla: A Case Report
15. Neville BW, Damm DD, Allen CM, et al. Epithelial patho- logy. Chapter 10. In Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Elsevier, 2009;362-452.
16. Prasad ML, Patel SG, Busam KJ. Primary mucosal desmoplastic melanoma of the head and neck. Head Neck 2004;26:373-7.
17. Messina JL, Glass LF, Cruse CW, et al. Pathologic examination of the sentinel lymph node in malignant melanoma. Am J Surg Pathol 1999:23;686-90.
18. Casiraghi O, Lefèvre M. Undifferentiated malignant round cell tumors of the sinonasal tract and nasopharynx. Ann Pathol 2009;29:296-312.
19. Strauss J, Strauss S. Oral malignant melanoma: a case report and review of the literature. J Oral Maxillofac Surg 1994;52:972-6.
20. Magliocca KR, Rand MK, Su LD, et al. Helman. Mela- noma-in-situ of the oral cavity. Oral Oncology EXTRA 2006:42;46-8.
21. Rapidis AD, Apostolidis C, Vilos G, et al. Primary malignant melanoma of the oral mucosa. J Oral Maxil- lofac Surg 2003;61:1132-9.