Usefulness of Arterial Spin Labeling-Tumor Blood Flow and Dynamic Contrast-Enhanced Perfusion Techniques in Predicting Treatment Response of Nasopharyngeal Carcinoma

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Dittapong Songsaeng, MD
Natthawut Jarunnarumol, MD
Kullathorn Thephamongkhol, MD
Jiraporn Setakornnukul, MD
Niyada Anusasnee, MD

Abstract

OBJECTIVES: To demonstrate the usefulness of arterial spin labeling (ASL)- tumor blood flow (TBF) and dynamic contrast enhancement (DCE) parameters in predicting the treatment response in patients with nasopharyngeal carcinoma (NPC) after 3-months of radiotherapy.


MATERIALS AND METHODS: Ten NPC patients who underwent magnetic resonance imaging (MRI) examinations with both ASL-TBF and DCE techniques before treatment and at the 3-month follow-up after radiotherapy were divided into complete-response (CR) and partial-response (PR) groups according to the Revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline version 1.1. The ASL-TBF and DCE parameters of the nasopharynx comprised TBF, Ktrans, IAUGC, Kep, and Ve were analyzed and compared between the two groups.


RESULTS: The CR group had a significantly higher pre-treatment Ve ratio (p = 0.038), a higher post-treatment TBF value (p = 0.038), and a higher post-treatment K trans value (p = 0.067) than the PR group.


CONCLUSION: The ASL-TBF and DCE techniques might be useful tools for the prediction of the treatment responses 3-months after radiotherapy in patients with NPC.

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1.
Songsaeng, MD D, Jarunnarumol, MD N, Thephamongkhol, MD K, Setakornnukul, MD J, Anusasnee, MD N. Usefulness of Arterial Spin Labeling-Tumor Blood Flow and Dynamic Contrast-Enhanced Perfusion Techniques in Predicting Treatment Response of Nasopharyngeal Carcinoma. BKK Med J [Internet]. 2021Sep.29 [cited 2021Oct.22];17(2):132. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/250507
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