The Efficiency of SGLT2 Inhibitors in Type 2 Diabetes and their Prevention of Renal and Cardiovascular Disease
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OBJECTIVES: To compare the effectiveness of sodium glucose co-transporter subtype 2 (SGLT2) inhibitors in preventing cardiovascular and renal disease in Type 2 diabetes patients with standard treatment.
MATERIALS AND METHODS: This study was conducted using experimental research with two-groups. All data were collected from the HIMPRO program from 1st October 2016 to 30th September 2021. A Fisher exact test was used to analyze the data to determine the relative risk reduction (RRR).
RESULTS: 237 diabetes patients were significantly eligible for SGLT2 inhibitors; 102 received SGLT2 inhibitors, and 135 received standard treatment. Annual follow-ups were scheduled for 4 consecutive years. The RRR for prevention of major adverse cardiovascular events (MACEs) in the first to fourth year were (86.8% (p < 0.05), 74.3% (p < 0.05), 67.2% (p < 0.05), and 66.3% (p < 0.05), respectively. The RRR for prevention of renal outcomes (ROs) were 55.9%, 68.8%, 83.6% (p < 0.001), and 84.3% (p < 0.001), respectively.
CONCLUSION: SGLT2 inhibitors, while being prescribed in Type-2 diabetic patients, indicated a statistically significant benefit in the prevention of cardiovascular disease in the first year and with significant benefit in preventing renal disease in the third and fourth years of use.
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